Results 81 to 90 of about 6,946 (259)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Managing Coal Mine Closure

, 2018
Over the last half century, large-scale changes to coal industries across Europe, and more recently in the United States and China, have resulted in as many as 4 million coal workers losing their jobs. The main drivers of these changes are mine mechanization, government policies and ...
openaire   +3 more sources

Coal mine closure substantially increases terrestrial water storage in China

Communications Earth & Environment
The transition away from coal involves the widespread closure of coal mines. While the potential adverse consequences of these closures on industry and the local economy have received considerable attention, empirical evidence on the benefits of water ...
Rong Ma, Junlian Gao, ChengHe Guan, Bo Zhang   +3 more
doaj   +1 more source

Characteristics of Carbon Monoxide and Ethylene Generation in Mine’s Closed Fire Zone and Their Influence on Methane Explosion Limits

Fire
Methane explosions often occur during the closure process of mine fire zones, during which the concentration of combustible gases such as monoxide and ethylene produced by coal combustion dynamically changes, which changes the risk of methane explosion ...
Dong Ma, Leilin Zhang, Tingfeng Zhu, Zhenfang Shi   +3 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Study on the prevention system of rockburst for the entire life cycle of underground coal mines

矿业科学学报
The existing prevention and control of rockbursts in mining mainly focus on the production phase, making it challenging to fundamentally curb rockburst disasters.
OUYANG Zhenhua, XU Qianhai, ZHANG Ningbo, ZHANG Tianzi, YI Haiyang, SHI Qingwen, LI Wenshuai, WANG Jiajia   +7 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Experimental simulation on the electrochemical mechanism of iron pollution from “dual-source” in closed coal mine water

Meitan kexue jishu
The closed coal mine water is mostly characterized by high iron. After mine closure and flooding, residual iron-prone devices and iron-bearing minerals form a “dual-source” iron pollution system in mine water, contributing to the release of iron in ...
Lai ZHOU, Tao YE, Shuangshuang ZHENG, Xueqiang ZHU, Jiangfeng WU   +4 more
doaj   +1 more source