Results 91 to 100 of about 5,070,469 (292)

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Risk Assessment of Coal Mine Ventilation System Based on Fuzzy Polymorphic Bayes: A Case Study of H Coal Mine

Systems
Coal mine ventilation systems face coupled and systemic risks characterized by structural interconnection and disaster chain propagation. In order to accurately quantify and evaluate this overall system risk, this study presents a new method of risk ...
Jin Zhao, Juan Shi, Jinhui Yang
doaj   +1 more source

Research on opposition-based enhanced fireworks algorithm optimization for mine ventilation network

Gong-kuang zidonghua, 2019
A non-linear unrestraint optimization model of mine ventilation network was established which took the minimum total energy consumption of mine ventilation network as optimization objective.
WU Xinzhong, HU Jianhao, WEI Lianjiang, QIAN Xiaoyu, REN Zihui, ZHANG Zhichao   +5 more
doaj   +1 more source

Guidelines on setting the target minute ventilation in Adaptive Support Ventilation

, 2021
Adaptive Support Ventilation (ASV) is a fully closed loop ventilation where the operator input the desired PEEP, FiO2 and the target minute ventilation (MV) expressed as a percentage according to ideal body weight.
Arnal, Jean-Michel, Daoud, Ehab, Ehab G. Daoud, Jean-Michel Arnal   +3 more
core   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

The Challenge of Measuring Airflow Through Mine Regulators to Allow Real Time Ventilation Monitoring

, 2002
The mathematical modeling of airflow through operating mine regulators is discussed. Results are used in the development of a computerized monitoring and simulation system to provide immediate or real time data on air behavior within each branch within ...
Mayes, Timothy I., Gillies, Stewart, Wu, Hsin Wei, Halim, A.   +3 more
core   +1 more source

Physics‐Aware Machine‐Learning‐Driven Inverse Design of Broadband Ultra‐Open Acoustic Metamaterials

Advanced Science, EarlyView.
A physics‐aware machine‐learning framework enables inverse design of ultra‐open acoustic silencers by decoupling spectral and radial design spaces. The approach rapidly identifies broadband, compact, and highly ventilated architectures, while revealing hidden linear design rules that link geometry, impedance matching, and acoustic performance.
Zhiwei Yang, Mengyu Li, Xiaohang Xie, Ao Chen, Thomas G. Bifano, Xin Zhang   +5 more
wiley   +1 more source

Advancing Energy Efficiency in Smart Windows via Dual‐Responsive Electro‐Thermochromism

Advanced Science, EarlyView.
A durable and stable quasi‐solid‐state electro‐thermal dual‐responsive photothermal regulation device has been employed in advanced energy‐efficient smart windows. The devised device not only incorporates a thermochromic hydrogel characterized by high ionic conductivity, high optical transmittance, and a low LCST, but also comprises an electrochromic ...
Tongyu Chen, Bing Xu, Guolong Zhou, Wenting Wu, Bingkun Huang, Xiaohui Tang, William W. Yu, Pooi See Lee, Wu Zhang, Zhongyang Wang, Jingwei Chen   +10 more
wiley   +1 more source

Spontaneous Combustion and Simulation of Mine Fires and Their Effects on Mine Ventilation Systems

, 2005
The structure of a comprehensive research project into mine fires study applying the Ventgraph mine fire simulation software, preplanning of escape scenarios and general interaction with rescue responses is outlined.
Gillies, Stewart, Wu, Hsin Wei, Humphreys, D.   +2 more
core   +1 more source