Results 71 to 80 of about 6,443,450 (298)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Geochemical Classification of Global Mine Water Drainage

open access: yesSustainability, 2020
This paper evaluates the geochemical distribution and classification of global Acid Mine Drainage (AMD) sources. The geochemical compositions of AMD from 72 mine water sites in 18 countries across 6 continents were referenced from literature.
S. K. Thisani, D. Kallon, P. Byrne
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Identification of Mine Water Inrush Source Based on PCA-FDA: Xiandewang Coal Mine Case

open access: yes, 2020
When mine water inrush accidents occur, timely and accurately identifying the water inrush source plays an important role in determining the cause of water inrush and making a solution to a disaster.
Bo Li, Qiang Wu, Zijie Liu
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Mineralogical and Thermochemical Characteristics of Dolomite Induced by Two Marine Microorganisms: Further Insights into Biomineralization

open access: yesCrystals
The mechanism of dolomite has been a major hotspot in geological research. However, most of the current studies mainly focus on single microorganisms and fail to fully consider the influence of marine microbial diversity on the precipitation of carbonate
Dingxiang Zhuang   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Numerical research on disastrous mechanism of seepage instability of karst collapse column considering variable mass effect

open access: yesScientific Reports
In order to reveal the disastrous mechanism of seepage instability of karst collapse column considering variable mass effect, a variable mass fluid–solid coupling mechanical model of water inrush is established, by considering the random distribution ...
Cao Zhengzheng   +5 more
doaj   +1 more source

Multi-factors model of pores geometries interplayingly affecting spontaneous imbibition in reservoir rock

open access: yesMeitan kexue jishu
China is short of natural gas resources, and these low-permeable reservoirs (such as tight gas, shale gas and coalbed methane) being difficultly developed account for a large proportion. How to efficiently developed this part of strategic resources is of
Chuanlong DONG   +2 more
doaj   +1 more source

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