Results 71 to 80 of about 69,562 (265)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A new determination method of hydraulic support resistance in deep coal pillar working face
Scientific ReportsThis study addresses hydraulic support resistance determination in deep coal pillar caving faces at Zhaogu No. 2 Mine through integrated theoretical, numerical, and field analyses. Theoretical calculations (empirical estimation: ≥ 15.742 MN; dynamic load
Guo-Dong Li +5 more
doaj +1 more source
CrystalsCohesive soil in the reservoir area is vulnerable to natural disasters because of its poor erosion resistance and low strength. Therefore, it needs to be reinforced.
Xinfa Li, Dingxiang Zhuang, Ru Hu
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Field application and diffusion law of grouting slurry in floor aquifer of a coal mine
Scientific ReportsFloor aquifers are responsible for approximately 55% of water inrush incidents in coal mines. As mining depths increase, the risk posed by confined floor aquifers becomes more severe.
Cao Zhengzheng +6 more
doaj +1 more source
Meitan xuebaoTo explore the microbial community characteristics and their response to environmental factors in different environmental areas of an underground coal mine, a study was conducted in the Xieqiao coal mine in Huainan, Anhui.
Haitao ZHANG +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
CrystalsThe mechanism of dolomite has been a major hotspot in geological research. However, most of the current studies mainly focus on single microorganisms and fail to fully consider the influence of marine microbial diversity on the precipitation of carbonate
Dingxiang Zhuang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Meitan kexue jishuChina is short of natural gas resources, and these low-permeable reservoirs (such as tight gas, shale gas and coalbed methane) being difficultly developed account for a large proportion. How to efficiently developed this part of strategic resources is of
Chuanlong DONG +2 more
doaj +1 more source