Results 71 to 80 of about 98,174 (313)
Microbial diversity and biogenic methane potential of a thermogenic-gas coal mine [PDF]
, 2014 The microbial communities and biogenic methane potential of a gas coal mine were investigated by cultivation-independent and cultivation-dependent approaches.
Wei, Min +3 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2022 S.1280-1286Membrane electrolysis processes can be appealing alternatives to other mine water treatment processes, especially for the selective separation and recovery of pollutants. The RODOSAN (R) process was developed for the simultaneous separation of
Friedrich, H.J.
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Development of a Natural Laboratory for the Study of Acid Mine Drainage [PDF]
, 1968 A small drift mine in Vinton County, Ohio, has been characterized and instrumented to permit a detailed study of the influence of oxygen concentration, microgiological factors, and hydrologic features on rate of pyrite oxidation within the system.
Smith, E. E., Shumate, K. S.
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Scientific ReportsIn order to reveal the disastrous mechanism of seepage instability of karst collapse column considering variable mass effect, a variable mass fluid–solid coupling mechanical model of water inrush is established, by considering the random distribution ...
Cao Zhengzheng +5 more
doaj +1 more source
, 2014 Weathered sulphidic mine waste is a major environmental problem. An experiment was performed in order to study water covers for oxidized mine waste. In two experiments oxidized mine waste were covered with water, in one experiment the fine fraction was ...
Sartz, Lotta,, Bäckström, Mattias,
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