Results 81 to 90 of about 6,443,450 (298)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Efficient Removal of Pb(II) and Cd(II) from Industrial Mine Water by a Hierarchical MoS2/SH-MWCNT Nanocomposite

ACS Omega, 2019
In this study, we investigate the adsorption capability of molybdenum sulfide (MoS2)/thiol-functionalized multiwalled carbon nanotube (SH-MWCNT) nanocomposite for rapid and efficient removal of heavy metals [Pb(II) and Cd(II)] from industrial mine water.
Rashi Gusain, Neeraj Kumar, E. Fosso-Kankeu, S. Ray   +3 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A new determination method of hydraulic support resistance in deep coal pillar working face

Scientific Reports
This study addresses hydraulic support resistance determination in deep coal pillar caving faces at Zhaogu No. 2 Mine through integrated theoretical, numerical, and field analyses. Theoretical calculations (empirical estimation: ≥ 15.742 MN; dynamic load
Guo-Dong Li, Xin-Lei Li, Heng-Heng Huan, Hai-Xiao Lin, Zi-Yuan Ren, Hao Ren   +5 more
doaj   +1 more source

Performance of Microbially Induced Carbonate Precipitation for Reinforcing Cohesive Soil in the Reservoir Area

Crystals
Cohesive soil in the reservoir area is vulnerable to natural disasters because of its poor erosion resistance and low strength. Therefore, it needs to be reinforced.
Xinfa Li, Dingxiang Zhuang, Ru Hu
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Microbial community characteristics and environmental response of water bodies in different environmental areas underground coal mine

Meitan xuebao
To explore the microbial community characteristics and their response to environmental factors in different environmental areas of an underground coal mine, a study was conducted in the Xieqiao coal mine in Huainan, Anhui.
Haitao ZHANG, Guangquan XU, Xiaoqing CHEN, Xu LI, Zixuan LI, Yanxi ZHANG, Gang ZHANG, Jianghui HE   +7 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mine and Water

Water
Environmental geology is a specialized field that examines the interaction between natural geological processes and human activities, particularly in the context of mineral resource extraction [...]
Ruiping Liu, Youning Xu
openaire   +2 more sources

Research on preventive technologies for bed-separation water hazard in China coal mines

Applied Water Science, 2018
Bed-separation water is one of the major water hazards in coal mines. Targeted researches on the preventive technologies are of paramount importance to safe mining.
Herong Gui, Shijie Tong, Weizhong Qiu, Manli Lin   +3 more
doaj   +1 more source