Does Mineralocorticoid Receptor Antagonism Prevent Calcineurin Inhibitor-Induced Nephrotoxicity? [PDF]
Frontiers in Medicine, 2017 Calcineurin inhibitors have markedly reduced acute rejection rates in renal transplantation, thus significantly improved short-term outcome. The beneficial effects are, however, tampered by acute and chronic nephrotoxicity leading to interstitial ...
Line Aas Mortensen +5 more
doaj +2 more sources
Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models [PDF]
Nature CommunicationsIntestinal fibrosis is a common complication in inflammatory bowel diseases with no specific therapy. Because mineralocorticoid receptor antagonism prevented inflammation and fibrosis in extra-intestinal organs, we aimed to evaluate mineralocorticoid ...
Asma Amamou +17 more
doaj +2 more sources
The Journal of Clinical HypertensionThe obesity pandemic, with its associated comorbidities of hypertension and diabetes, constitutes a global public health issue. Importantly, there is an increasing prevalence of aldosterone excess related to obesity and resultant poor health outcomes ...
Houry Puzantian +2 more
doaj +2 more sources
Apparent Mineralocorticoid Excess Syndrome: Case Report. [PDF]
Int Med Case Rep JAlsaadoun SA +3 more
europepmc +3 more sources
Bilateral Adrenal Masses with Different Aetiologies Presenting as Addisonian Crisis with Acute Kidney Injury: A Case Series [PDF]
Journal of Clinical and Diagnostic Research, 2023 An Addisonian Crisis (AC) is an endocrinological emergency associated with high mortality, resulting from an acute deficit of hormones from the adrenal glands.
Mohini +4 more
doaj +1 more source
Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor [PDF]
Endocrinology and Metabolism, 2021 Background Despite clinical evidence indicating poor muscle health in subjects with primary aldosteronism (PA), it is still unclear whether the role of aldosterone in muscle metabolism is direct or mediated indirectly via factors, such as electrolyte ...
Jin Young Lee +5 more
doaj +1 more source
case of liquorice-infused marijuana causing syndrome of apparent mineralocorticoid excess
European Journal of Case Reports in Internal Medicine, 2023 Marijuana has long been used both for recreational and medicinal purposes. Most of the available forms of marijuana contain additives such as liquorice to enhance its flavour. Liquorice increases the amounts of cortisol in the body and produces metabolic
Asnia Latif +2 more
doaj +1 more source
Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background The pathobiology of heart failure with preserved ejection fraction (HFpEF) is still poorly understood, and effective therapies remain limited.
Bence Hegyi +9 more
doaj +1 more source
Heterogeneous natural history of Addison’s disease: mineralocorticoid deficiency may predominate
Endocrine Connections, 2022 Autoimmune Addison’s disease (AAD) is defined as primary adrenal insufficiency due to immune-mediated destruction of the adrenal cortex. This destruction of steroid-producing cells has historically been thought of as an irreversible process, with linear ...
Sophie Howarth +3 more
doaj +1 more source
Journal of Veterinary Internal Medicine, 2023 Background Primary hypoadrenocorticism (PH) is rare in cats and knowledge about treatment is sparse. Objective To describe cats with PH with a focus on long‐term treatment. Animals Eleven cats with naturally occurring PH.
Nadja S. Sieber‐Ruckstuhl +8 more
doaj +1 more source