Physiological Reports, 2021 Restricting dietary sodium promotes sodium appetite in rats. Prolonged sodium restriction increases plasma potassium (pK), and elevated pK is largely responsible for a concurrent increase in aldosterone, which helps promote sodium appetite.
Frederico S. Fazan +3 more
doaj +1 more source
Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]
, 2018 Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R +8 more
core +2 more sources
Aldosterone Blocks Rat Stem Leydig Cell Development In Vitro
Frontiers in Endocrinology, 2018 Aldosterone (ALDO) is a primary endogenous mineralocorticoid, appearing as the main hormone controlling sodium and water homeostasis. Its emerging role in the development of many organs has gained interest over the past few years.
Jingwei Zhang +9 more
doaj +1 more source
Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]
, 1999 Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and ...
Arriza +39 more
core +5 more sources
Nuclear receptors in vascular biology [PDF]
, 2015 Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla +56 more
core +3 more sources
Vascular cell‐specific roles of mineralocorticoid receptors in pulmonary hypertension
Pulmonary Circulation, 2021 Abnormalities that characterize pulmonary arterial hypertension include impairment in the structure and function of pulmonary vascular endothelial and smooth muscle cells.
Divya P. Menon +10 more
doaj +1 more source
The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]
, 1993 There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Aktas, Janet +4 more
core +1 more source
Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes
Physiological Reports, 2021 Individuals with type 2 diabetes have an increased risk of cardiovascular disease. A correlation between plasma aldosterone and hyperinsulinemia has been demonstrated in vivo, and hyperinsulinemia and insulin resistance are independently associated with ...
Stine H. Finsen +4 more
doaj +1 more source
Comparison of different strategies to measure medication adherence via claims data in patients with chronic heart failure [PDF]
, 2019 Medication adherence correlates with morbidity and mortality in patients with chronic heart failure (CHF), but is difficult to assess. We conducted a retrospective methodological cohort study in 3,808 CHF patients, calculating adherence as proportion of ...
Griese‐Mammen, Nina +6 more
core +1 more source
Localization of mineralocorticoid receptors at mammalian synapses. [PDF]
PLoS ONE, 2010 In the brain, membrane associated nongenomic steroid receptors can induce fast-acting responses to ion conductance and second messenger systems of neurons.
Eric M Prager +4 more
doaj +1 more source