Results 51 to 60 of about 93,504 (350)

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Persistent isolated hypocortisolism following brief treatment with trilostane [PDF]

, 2008
A 12-year-old male neutered Miniature Poodle with confirmed pituitary-dependent hyperadrenocorticism was treated with trilostane. After three doses, it developed clinical and laboratory changes suggestive of isolated hypocortisolism ('atypical ...
Barker, Bell, Braddock, Chapman, Dunn, Eastwood, Feldman, Hoffman, Javadi, Kintzer, Lifton, Mantis, Neiger, Rao, Ruckstuhl, Russell, Sadek, Sieber-Ruckstuhl, Wenger, Witt   +19 more
core   +1 more source

Incidence, predictors and clinical management of hyperkalaemia in new users of mineralocorticoid receptor antagonists

European Journal of Heart Failure, 2018
Concerns for hyperkalaemia limit the use of mineralocorticoid receptor antagonists (MRAs). The frequency of MRA‐associated hyperkalaemia in real‐world settings and the extent of subsequent MRA discontinuation are poorly quantified.
Marco Trevisan, Pietro de Deco, Hairong Xu, M. Evans, B. Lindholm, R. Bellocco, P. Bárány, T. Jernberg, L. Lund, J. Carrero   +9 more
semanticscholar   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Evaluation of a low‐dose desoxycorticosterone pivalate treatment protocol for long‐term management of dogs with primary hypoadrenocorticism

Journal of Veterinary Internal Medicine, 2019
Background Lowering the dose of desoxycorticosterone pivalate (DOCP) for the treatment of dogs with primary hypoadrenocorticism (PH) decreases costs and could lead to increased owner motivation to treat their affected dogs.
Nadia S. Sieber‐Ruckstuhl, Claudia E. Reusch, Nathalie Hofer‐Inteeworn, Claudia Kuemmerle‐Fraune, Claudia Müller, Regina Hofmann‐Lehmann, Felicitas S. Boretti   +6 more
doaj   +1 more source

11β-HSD Types 1 and 2 in the Songbird Brain

Frontiers in Endocrinology, 2018
Glucocorticoid (GC) hormones act on the brain to regulate diverse functions, from behavior and homeostasis to the activity of the hypothalamic–pituitary–adrenal axis.
Michelle A. Rensel, Michelle A. Rensel, Jessica A. Ding, Devaleena S. Pradhan, Devaleena S. Pradhan, Barney A. Schlinger, Barney A. Schlinger, Barney A. Schlinger   +7 more
doaj   +1 more source

Treatment of dogs with compensated myxomatous mitral valve disease with spironolactone-a pilot study [PDF]

, 2017
Spironolactone improves outcome in dogs with advanced myxomatous mitral valve disease (MMVD). Its efficacy in preclinical MMVD is unknown. The hypothesis was the administration of spironolactone to dogs with compensated MMVD demonstrating risk factors ...
Boswood, A, Elliott, J, Hezzell, M J, Lopez-Alvarez, J, Lotter, N S   +4 more
core   +3 more sources

Cardiomyocyte glucocorticoid and mineralocorticoid receptors directly and antagonistically regulate heart disease in mice

Science Signaling, 2019
Skewing glucocorticoid signaling to favor mineralocorticoid receptor activation is detrimental to the heart. A balancing act for the heart Stress increases the risk of dying from cardiometabolic disease.
R. Oakley, D. Cruz-Topete, Bo He, J. Foley, P. Myers, Xiaojiang Xu, C. Gomez-Sanchez, P. Chambon, M. Willis, J. Cidlowski   +9 more
semanticscholar   +1 more source

Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón, Vahid Akbari, Ralph Rothstein, Alexandra Inman, Sanjiv Bhalla, Jianghong An, Jan M. Friedman, Rosanna Weksberg, Cornelius Boerkoel, Steven J. M. Jones, William T. Gibson   +10 more
wiley   +1 more source

Return to the workforce following first hospitalization for heart failure: a Danish nationwide cohort study [PDF]

, 2016
Background: Return to work is important financially, as a marker of functional status and for self-esteem in patients developing chronic illness. We examined return to work after first heart failure (HF) hospitalization.
Fosbøl, Emil L., Gerds, Thomas A., Gislason, Gunnar H., Jhund, Pardeep S., Kragholm, Kristian, Kristensen, Søren L., Køber, Lars, Lamberts, Morten, McMurray, John J.V., Mogensen, Ulrik M., Petrie, Mark C., Rørth, Rasmus, Torp-Pedersen, Christian, Wong, Chih   +13 more
core   +2 more sources