Results 81 to 90 of about 76,021 (334)

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY

open access: yesРациональная фармакотерапия в кардиологии, 2017
The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved
O. M. Drapkina, D. U. Akasheva
doaj   +1 more source

Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.
Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani   +11 more
wiley   +1 more source

Obesity, aldosterone excess, and mineralocorticoid receptor activation: Parallel or intersected circumstances?

open access: yesThe Journal of Clinical Hypertension
The obesity pandemic, with its associated comorbidities of hypertension and diabetes, constitutes a global public health issue. Importantly, there is an increasing prevalence of aldosterone excess related to obesity and resultant poor health outcomes ...
Houry Puzantian   +2 more
doaj   +1 more source

The effect of cumulative stress exposure on depressive symptoms is modified by a mineralocorticoid receptor haplotype

open access: yesEuropean Journal of Psychotraumatology, 2012
Rationale/statement of the problem : Stress exposure increases the risk for the development of depression. The leading hypothesis is that stress exposure only increases the risk in individuals combining a vulnerable genetic background with (repeated ...
Christian H. Vinkers   +6 more
doaj   +1 more source

Natural and Synthetic Corticosteroids Inhibit Uptake\u3csub\u3e2\u3c/sub\u3e-Mediated Transport in CNS Neurons [PDF]

open access: yes, 2011
In addition to exerting actions via mineralocorticoid and glucocorticoid receptors, corticosteroids also act by inhibiting uptake2, a high-capacity monoamine transport system originally described in peripheral tissues.
Gasser, Paul J.   +4 more
core   +1 more source

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

open access: yes, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt   +25 more
core   +2 more sources

Analysis of the usefulness and benefits of ultrafiltration in cardiorenal syndrome: A systematic review

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1194-1202, April 2025.
Abstract Aims Cardiac decompensation in cardiorenal syndrome (CRS) results in systemic congestion usually treated with diuretics. When despite high doses of diuretics, response is poor, ultrafiltration (UF) appears to be a useful and safe technique.
Borja Guerrero Cervera   +12 more
wiley   +1 more source

Editorial: Adrenal neuroendocrine system and cardiometabolic health: pathophysiology and clinical implications

open access: yesFrontiers in Endocrinology, 2023
Moe Thuzar   +4 more
doaj   +1 more source

A Young Patient with Leg Weakness and Hypokalemia—Case Report

open access: yesRambam Maimonides Medical Journal, 2018
A 20-year-old female patient was admitted to hospital because of bilateral leg weakness. Laboratory investigation showed metabolic alkalosis and severe hypokalemia.
Elias Andrawus   +2 more
doaj   +1 more source

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