Journal of Diabetes Investigation, EarlyView.ABSTRACT Aims/Introduction Oxidative stress is thought to play a role in the onset and progression of diabetic nephropathy (DN). Nuclear factor erythroid‐related factor 2 (Nrf2) is a master regulator of antioxidant and detoxification pathways and provides cellular protection against oxidative stress.
Suratsawadee Promsuwan +5 more
wiley +1 more source
In Silico Decoding of Nonsteroidal Mineralocorticoid Receptor Antagonist Binding: Implications for Drug Design. [PDF]
J Chem Inf ModelPérez-Gordillo F +3 more
europepmc +1 more source
Hip Fracture Risk of Lemborexant and Suvorexant in Comparison With Z‐Drugs: A Target Trial Emulation
Journal of the American Geriatrics Society, EarlyView.ABSTRACT Background Lemborexant and suvorexant are widely used dual orexin receptor antagonists (DORAs) for the pharmacological treatment of insomnia. Although they are generally considered safer than benzodiazepine receptor agonists (Z‐drugs) regarding adverse events including hip fractures, evidence from direct comparisons remains limited. This study
Yuichiro Matsuo +5 more
wiley +1 more source
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background The role of cardiac resynchronization therapy (CRT) during hospitalization for heart failure (HFH) is uncertain, because hospitalized patients were routinely excluded from landmark CRT trials. Despite this, CRT implantation during HFH is common.
Oliver Rees +5 more
wiley +1 more source
Advanced Conduction Disease After Incident Heart Failure in Myotonic Dystrophy Type 1
Pacing and Clinical Electrophysiology, EarlyView.Central Figure. Advanced Conduction Disease After Incident HF in Myotonic Dystrophy Type 1. ABSTRACT Background Myotonic dystrophy type 1 (DM1) is associated with progressive cardiac conduction disease, heart failure (HF) and increased mortality. However, the association of incident HF with conduction disease and survival in DM1 is not well defined ...
Isadora Guarino +3 more
wiley +1 more source
Discrepancies between forest plots and reported results in mineralocorticoid receptor antagonist meta-analysis of glycaemic outcomes. [PDF]
Br J Clin PharmacolSaha L.
europepmc +1 more source
Experimental Physiology, EarlyView.Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores +4 more
wiley +1 more source
Interpreting the Association Between Diuretic Intensity Score and Mortality: The Potential Roles of Diuretic Responsiveness and Mineralocorticoid Receptor Antagonist Therapy. [PDF]
Clin CardiolImamura T.
europepmc +1 more source
Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells
The Journal of Physiology, EarlyView.Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski +3 more
wiley +1 more source
Trends in Steroidal Mineralocorticoid Receptor Antagonist Prescriptions by Nephrologists after Approval of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone for CKD. [PDF]
J Am Soc NephrolEdmonston D, Catanese B, Sparks M.
europepmc +1 more source