Results 151 to 160 of about 18,037 (235)

Toward a digital urinary biopsy for early risk stratification in diabetic kidney disease: Anchoring shed cells, vesicles, and cell‐free DNA to spatial kidney cell states

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
In diabetic kidney disease, one urine specimen carries shed cells, extracellular vesicles and cell‐free DNA released along the whole nephron. Reading all three against spatial kidney atlases is proposed as a testable route to cell‐resolved, non‐invasive risk stratification, and the clinical outputs shown are not yet demonstrated.
Juan Wu, Ping Sheng, Ying Lu, Ke Chen
wiley   +1 more source

Pharmacology and Therapeutic Potential of Finerenone: A Novel Third-Generation Nonsteroidal Mineralocorticoid Receptor Antagonist. [PDF]

Cureus
Ramadan MM, Alajmi S, Aldouseri J, Alajmi M, Tello EA, Mahdi AO, Aladwani AJ, Alayyaf AE, Mahdi O, Elmahal M.   +9 more
europepmc   +1 more source

Fermented Noni Juice Supplementation Attenuates Heart Failure Development in Mice: Involvement of the Pentose Phosphate Pathway

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Morinda citrifolia L., commonly known as Noni, is a traditional medicinal plant that has long been utilized in various cultures for its anti‐inflammatory and antioxidant properties. Heart failure (HF) is a significant and growing public health concern worldwide that is characterized by substantial morbidity, mortality, and healthcare costs ...
Min Zhang, Xia Guan, Ruize Lu, Zhangxin Yu, Xuanjia Chen, Jingyao Xu, Guangying Chen, Haiying Zhang, Yan Liu   +8 more
wiley   +1 more source

Mineralocorticoid Receptor Antagonist Pre-Adrenalectomy in Primary Aldosteronism.

J Clin Endocrinol Metab
Goi J, Paja Fano M, Rizo Gellida A, González-Boillos M, Martín Rojas-Marcos P, Caja Guayerbas L, García Cano AM, Ruiz-Sanchez JG, Vicente A, Gómez-Hoyos E, Recasens M, Barahona San Millan R, Picón César MJ, Díaz Guardiola P, Perdomo CM, Manjón-Miguélez L, Rebollo Román Á, Robles Lázaro C, Recio-Cordova JM, Calatayud M, Jiménez López N, Sampedro Nuñez M, Mena Ribas E, Sanmartín Sánchez A, Gonzalvo Diaz C, Lamas C, Serrano J, Michalopoulou T, Tenes Rodrigo S, Pascual-Corrales E, Jaén Aguila F, Muñoz Rivas N, Moya Mateo EM, Gutiérrez-Medina S, Hanzu FA, Parra Ramírez P, Araujo-Castro M.   +36 more
europepmc   +1 more source

Safety and efficacy of early initiation of mineralocorticoid receptor antagonist after an acute decompensated heart failure event or acute myocardial infarction with cardiac dysfunction: a meta-analysis of randomized clinical trials. [PDF]

ESC Heart Fail
Laborante R, Paglianiti DA, Elia S, Patti G, Girerd N, Savarese G, D'Amario D.   +6 more
europepmc   +1 more source

Resource management and clinical outcomes during a national intravenous fluid shortage

Journal of Hospital Medicine, Volume 21, Issue 11, Page 1244-1251, November 2026.
Abstract Background A natural disaster, Hurricane Helene, damaged a production facility supplying 60% of intravenous (IV) fluids in the United States. A nationwide IV fluid shortage followed. Objectives To evaluate a multifaceted IV fluid conservation intervention's effect on IV fluid utilization and clinical outcomes during the shortage.
Stacy A. Johnson, Erin R. Fox, Smitha Warrier, Russell Vinik   +3 more
wiley   +1 more source

Association Between Mineralocorticoid Receptor Antagonist Use With Worsening Renal Function and Prognosis in Patients With Acute Heart Failure. [PDF]

J Am Heart Assoc
Fujimoto Y, Shiraishi Y, Nogi K, Kohsaka S, Kohno T, Kitamura M, Nagatomo Y, Ueda T, Nogi M, Ishihara S, Nakada Y, Kawakami R, Kitai T, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Kida K, Okumura T, Yoshikawa T, Saito Y, Matsue Y.   +21 more
europepmc   +1 more source

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source

Observation of the therapeutic effect of finerenone, a novel non-steroidal mineralocorticoid receptor antagonist, in patients with non-diabetic CKD. [PDF]

Ren Fail
Li F, Han J, Zhang W, Lv J, Wang Z, Li H, Jin L, Feng J, Lu W, Sun J.   +9 more
europepmc   +1 more source

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Takeshi Marumo, Toshiro Fujita   +6 more
wiley   +1 more source