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Kidney Disease and Mineralocorticoid Receptor
Nihon Naika Gakkai Zasshi, 2009 openaire +3 more sources
Microvillus Inclusion Disease: Successful Treatment of Severe Hyponatremia With High-Dose Fludrocortisone via a Possible Gut-Mediated Mechanism. [PDF]
ACG Case Rep JAlsarhan A +4 more
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Licorice-Induced Pseudohyperaldosteronism Highlights an Underestimated Etiology of Hypertension. [PDF]
Kidney Int RepBendjilali-Sabiani JJ +6 more
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A rare case of apparent mineralocorticoid excess induced by chronic liquorice ingestion. [PDF]
Endocrinol Diabetes Metab Case RepRoy A, Mullins K.
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Molecular mechanism for pancreatic β-cell dysfunction and atherosclerosis. [PDF]
Diabetol IntKaneto H.
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Roles of Mineralocorticoid Receptors in Cardiovascular and Cardiorenal Diseases.
Annual Review of Physiology, 2022Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained inflammation.
J. Barrera-Chimal +2 more
semanticscholar +1 more source
Current Hypertension Reports, 2020
Recently, nonsteroidal mineralocorticoid receptor (MR) antagonists (MRAs), which have been proposed to be called MR blockers (MRBs), have become available for clinical use, but their clinical role is unknown. We reviewed the clinical roles of MRAs and MRBs based on previous knowledge and as demonstrated in representative clinical trials.Steroidal MRAs,
Daisuke, Sueta +2 more
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Recently, nonsteroidal mineralocorticoid receptor (MR) antagonists (MRAs), which have been proposed to be called MR blockers (MRBs), have become available for clinical use, but their clinical role is unknown. We reviewed the clinical roles of MRAs and MRBs based on previous knowledge and as demonstrated in representative clinical trials.Steroidal MRAs,
Daisuke, Sueta +2 more
openaire +2 more sources
, 2020
The glucocorticoid hormones cortisol and corticosterone coordinate circadian events and are master regulators of the stress response. These actions of the glucocorticoids are mediated by mineralocorticoid receptors (NR3C2, or MRs) and glucocorticoid ...
E. D. Kloet, M. Joëls
semanticscholar +1 more source
The glucocorticoid hormones cortisol and corticosterone coordinate circadian events and are master regulators of the stress response. These actions of the glucocorticoids are mediated by mineralocorticoid receptors (NR3C2, or MRs) and glucocorticoid ...
E. D. Kloet, M. Joëls
semanticscholar +1 more source
Mineralocorticoid receptor antagonists
Current Hypertension Reports, 2007With an increasingly aging population, the need for effective treatment of cardiovascular diseases (eg, heart failure, hypertension, and ischemic heart disease) cannot be overemphasized. The vital importance of mineralocorticoid receptor antagonists for treating cardiovascular conditions has only been appreciated in the last decade. The re-emergence of
Parthasarathy, Hari Krishnan +1 more
openaire +3 more sources