Results 41 to 50 of about 21,522 (206)

The mineralocorticoid receptor forms higher order oligomers upon DNA binding [PDF]

, 2023
Grégory Fettweis, Thomas A. Johnson, Brian Almeida‐Prieto, Julián Weller‐Pérez, Diego M. Presman, Gordon L. Hager, Diego Álvarez de la Rosa   +6 more
openalex   +1 more source

Evidence for Aldosterone Antagonism in Heart Failure

Cardiac Failure Review
Activation of the renin–angiotensin–aldosterone system is the ultimate pathophysiological hallmark in heart failure. Though aldosterone primarily appears to regulate electrolyte homeostasis by acting on distal nephrons in the kidneys, its effects are far-
Rishi Sethi, Pravesh Vishwakarma, Akshyaya Pradhan   +2 more
doaj   +1 more source

MINERALOCORTICOID RECEPTOR ANTAGONISTS THERAPY IN RESISTANT HYPERTENSION: TIME TO IMPLEMENT NEW GUIDELINES?

Frontiers in Cardiovascular Medicine, 2015
Despite the availability of anti-hypertensive medications with increasing efficacy up to 50% of hypertensive patients have blood pressure levels (BP) not at the goals set by international societies.
Giuseppe eMaiolino, Matteo eAzzolini, Gian Paolo eRossi   +2 more
doaj   +1 more source

Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design [PDF]

, 2021
Isabella B. Stone, Jessica A.E.M. Green, Andrew W Koefoed, Ezra S. Hornik, Jonathan S. Williams, Gail K. Adler, Gordon H. Williams   +6 more
openalex   +1 more source

Disruption of Glucocorticoid and Mineralocorticoid Receptor-Mediated Responses by Environmental Chemicals

CHIMIA, 2008
Glucocorticoids and mineralocorticoids are key endocrine hormones modulating essential physiological processes such as energy metabolism, cell growth and differentiation, maintenance of blood pressure and immune responses.
Alex Odermatt, Christel Gumy
doaj   +1 more source

FIDELIO study: significance and place of finerenone as nonsteroidal mineralocorticoid receptor antagonist in therapy of patients with chronic kidney disease in type 2 diabetes [PDF]

, 2023
Минара Шамхаловна Шамхалова, O. Yu. Sukhareva, M. I. Yevloyeva   +2 more
openalex   +1 more source

Therapeutic Potential of Mineralocorticoid Receptors in Skeletal Muscle Aging

Receptors
Skeletal muscle aging, or sarcopenia, involves progressive muscle mass and function loss, which limits mobility and independence in elderly populations.
Ricardo Aparecido Baptista Nucci, Otávio de Toledo Nóbrega, Wilson Jacob-Filho   +2 more
doaj   +1 more source

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.

PLoS ONE, 2020
Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticosterone
John R Pooley, Caroline A Rivers, Michael T Kilcooley, Susana N Paul, Ayse Derya Cavga, Yvonne M Kershaw, Serena Muratcioglu, Attila Gursoy, Ozlem Keskin, Stafford L Lightman   +9 more
doaj   +1 more source

SM-368229, a Novel Selective and Potent Non-steroidal Mineralocorticoid Receptor Antagonist With Strong Urinary Na+ Excretion Activity

Journal of Pharmacological Sciences, 2011
Mineralocorticoid receptor (MR) antagonists, such as spironolactone (SPI) and eplerenone (EPL), are useful for the treatment of hypertension and heart failure.
Tetsuro Nariai, Katsuya Fujita, Masaya Mori, Seiji Katayama, Seiji Hori, Kazuki Matsui   +5 more
doaj   +1 more source

Mineralocorticoid modulation of central angiotensin-induced neuronal activity, water intake and sodium appetite

Brazilian Journal of Medical and Biological Research, 2007
Central angiotensin II (AngII) stimulates water and salt solution intake. Pretreatment with low-dose mineralocorticoid (DOCA) enhances this AngII-induced intake of salt solutions (the synergy theory) in Wistar and Sprague Dawley rats but not in Fischer ...
S.N. Thornton, S.T. Omouessi, C. Falconetti   +2 more
doaj   +1 more source