Results 41 to 50 of about 2,343,081 (240)

PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY

Рациональная фармакотерапия в кардиологии, 2017
The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved
O. M. Drapkina, D. U. Akasheva
doaj   +1 more source

A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI [PDF]

, 2013
BACKGROUND: Acute kidney injury (AKI) is a frequent condition in hospitalised patients undergoing major surgery or the critically ill and is associated with increased mortality.
Delles, C., Husi, H., Mischak, H., Mullen, W., Ortiz, A., Sanchez-Niño, M., Vlahou, A.   +6 more
core   +3 more sources

Non-genomic Actions of Methylprednisolone Differentially Influence GABA and Glutamate Release From Isolated Nerve Terminals of the Rat Hippocampus

Frontiers in Molecular Neuroscience, 2020
Corticosteroids exert a dual role in eukaryotic cells through their action via (1) intracellular receptors (slow genomic responses), or (2) membrane-bound receptors (fast non-genomic responses).
Rafael Neiva, Rafael Neiva, Ana Caulino-Rocha, Ana Caulino-Rocha, Fátima Ferreirinha, Fátima Ferreirinha, Maria Graça Lobo, Maria Graça Lobo, Paulo Correia-de-Sá, Paulo Correia-de-Sá   +9 more
doaj   +1 more source

The role of mineralocorticoid receptors hyperactivation in the development of cardiorenal complications in patients with diabetes mellitus, perspective of the selective nonsteroidal mineralocorticoid receptors antagonist’s treatment: A review

Терапевтический архив, 2023
The renin-angiotensin-aldosterone system (RAAS) activation plays a key role in the chronic kidney disease (CKD) progression and in the cardiovascular complications (CVC) development in patients with diabetes mellitus (DM).
Irina N. Bobkova
doaj   +1 more source

Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2 [PDF]

, 1999
Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid receptors, causing sodium retention, hypokalemia, and ...
Arriza, Benediktsson, Berl, Brown, Brown, Chomczynski, Christopher Kenyon, Christopher R.W. Edwards, Clark, Cole, Edwards, Fleming, Gordon, Grone, Grunder, Guyton, Jamieson, John J. Mullins, Jonathan R. Seckl, Kaissling, Kotelevtsev, Krozowski, Lifton, Lindsay, Low, Millar, Mune, Nehls, Roger W. Brown, Sharp, Shimkets, Simon, Stewart, Stewart, Stewart, Stewart Fleming, Ulick, White, White, Yuri Kotelevtsev   +39 more
core   +5 more sources

The role of aldosterone in the development of atrial fibrillation: modern understanding of problem

Архивъ внутренней медицины, 2019
The review of literature presents modern ideas about the role of aldosterone in the development and maintenance of atrial fibrillation. It is shown that hormone takes part in all stages of the electrophysiological and structural atrial remodeling ...
N. T. Vatutin, A. N. Shevelok, I. N. Kravchenko   +2 more
doaj   +1 more source

Glucocorticoid feedback paradox: a homage to Mary Dallman

Stress, 2023
As the end product of the hypothalamus-pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone coordinate circadian activities, stress-coping, and adaptation to change.
Edo Ronald de Kloet
doaj   +1 more source

Evolution of human, chicken, alligator, frog, and zebrafish mineralocorticoid receptors: Allosteric influence on steroid specificity

Science Signaling, 2017
Analysis of the interactions of multiple steroid ligands with the mineralocorticoid receptor identifies domains involved in activation and inhibition. Evolving steroid responses Mineralocorticoid receptors (MRs) are members of the nuclear receptor family
Y. Katsu, Kaori Oka, M. Baker
semanticscholar   +1 more source

Effects of environmental enrichment on behavioral responses to novelty, learning, and memory, and the circadian rhythm in cortisol in growing pigs [PDF]

, 2000
Previously we showed that pigs reared in an enriched environment had higher baseline salivary cortisol concentrations during the light period than pigs reared under barren conditions.
Blokhuis, Harry J.,, Burgwal, Johan A. van de,, Jong, Ingrid C. de,, Koolhaas, Jaap M.,, Korte, S. Mechiel,, Lambooij, Elbert,, Prelle, Ina T.,   +6 more
core   +1 more source

Experimental rat models of chronic allograft nephropathy: a review [PDF]

, 2014
Chronic allograft nephropathy (CAN) is the leading cause of late allograft loss after renal transplantation (RT), which continues to remain an unresolved problem. A rat model of CAN was first described in 1969 by White et al. Although the rat model of RT
Haylor, John, Shrestha, Badri
core   +2 more sources