Results 21 to 30 of about 1,341,600 (296)

Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation [PDF]

Kidney International Reports, 2022
Minimal change disease (MCD) is considered a podocyte disorder triggered by unknown circulating factors. Here, we hypothesized that the endothelial cell (EC) is also involved in MCD.We studied 45 children with idiopathic nephrotic syndrome (44 had steroid sensitive nephrotic syndrome [SSNS], and 12 had biopsy-proven MCD), 21 adults with MCD, and 38 ...
Bauer, C., Piani, F., Banks, M., Ordo(~n)ez, F. A., de Lucas-Collantes, C., Oshima, K., Schmidt, E. P., Zakharevich, I., Segarra, A., Martinez, C., Roncal-Jimenez, C., Satchell, S. C., Bjornstad, P., Lucia, M. S., Blaine, J., Thurman, J. M., Johnson, R. J., Cara-Fuentes, G.   +17 more
openaire   +3 more sources

Definition of minimal disease activity in psoriasis

Journal of the European Academy of Dermatology and Venereology, 2020
AbstractObjectiveTo generate an operational definition to adequately reflect the construct ‘Minimal Disease Activity (MDA)’ in psoriasis.MethodsA systematic review of domains included in clinical trials of psoriasis was presented to a panel of dermatologists and patients. Further domains were elicited by panel discussions.
Carretero G, Carrascosa J, Puig L, Sanchez-Carazo J, Lopez-Ferrer A, Cueva P, Soria C, Rivera R, Belinchon I, Spanish Acad Dermatology Venereolo   +9 more
openaire   +8 more sources

Search for predictors of achieving minimal disease activity during tofacitinib therapy in patients with psoriatic arthritis

Современная ревматология, 2023
Objective: to search predictors of achieving minimal disease activity (MDA) during therapy in patients with psoriatic arthritis (PsA).Materials and methods.
L. D. Vorobyova, T. V. Korotaeva, S. I. Glukhova, E. Yu. Loginova, E. E. Gubar, Yu. L. Korsakova   +5 more
doaj   +1 more source

Patient characteristics and minimal disease activity in psoriatic arthritis: a transcontinental comparison

Clinical Rheumatology, 2021
Psoriatic arthritis (PsA) is a heterogeneous disease with both environmental and genetic factors playing a role in this diversity. The aim of this study is to compare the patient profiles and outcomes in PsA patients in three countries from three continents.
Bakirci, Sibel, Ayan, Gizem, Gazel, Ummugulsum, Tinazzi, Ilaria, Solmaz, Dilek, Kasapoglu, Esen, Kalyoncu, Umut, Aydin, Sibel Zehra   +7 more
openaire   +3 more sources

Comparative efficacy of tofacitinib and adalimumab in patients with psoriatic arthritis in real clinical practice. Data from the Russian nationwide register of patients with psoriatic arthritis

Современная ревматология, 2021
Objective: to compare the clinical efficacy in real clinical practice of the targeted synthetic disease-modifying antirheumatic drug (sDMARD) tofacitinib (TOFA) and the biologic DMARD (bDMARD), an inhibitor of tumor necrosis factor alpha (TNFα ...
E. Yu. Loginova, T. V. Korotaeva, E. E. Gubar, Yu. L. Korsakova, S. I. Glukhova, E. A. Vasilenko, A. A. Vasilenko, N. A. Kuznetsova, I. M. Patrikeyeva, E. L. Nasonov   +9 more
doaj   +1 more source

Minimal Change Disease Is Associated with Mitochondrial Injury and STING Pathway Activation [PDF]

Journal of Clinical Medicine, 2022
We hypothesized that minimal change disease (MCD) pathogenesis may be associated with mitochondrial injury, and that the degree of mitochondrial injury at the time of diagnosis may serve as a valuable prognostic marker. We compared urinary mitochondrial DNA (mtDNA) at the time of diagnosis in patients with MCD and age- and sex-matched healthy controls (
Byung Chul Yu, Ahrim Moon, Kyung Ho Lee, Young Seung Oh, Moo Yong Park, Soo Jeong Choi, Jin Kuk Kim   +6 more
openaire   +2 more sources

Prognostic factors associated with achieving minimal disease activity in early psoriatic arthritis patients treated according to “treat-to-target” st rategy within 12 months

Научно-практическая ревматология, 2022
Background. The goal of “treat-to-target” strategy (T2T) in psoriatic arthritis (PsA) is attaining remission or minimal disease activity (MDA). The benefits of T2T are shown recently in the study TICOPA and REMARCA. But prognostic factors for achievement
E. Yu. Loginova, T. V. Korotaeva, E. E. Gubar, S. I. Glukhova   +3 more
doaj   +1 more source

SAT0381 MINIMAL DISEASE ACTIVITY IN PSORIATIC ARTHRITIS PREDICTS LOW IMPACT OF DISEASE [PDF]

Annals of the Rheumatic Diseases, 2019
Background: Psoriatic arthritis (PsA) is the commonest form of inflammatory spondyloarthropathy with prevalence of 0.19% in UK. Patients suffering from PsA often have significant impact on daily life due to articular, non-articular and psychological symptoms.
Ganesh Kasavkar, Siwalik Banerjee, Nicola Gullick   +2 more
openaire   +1 more source

Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir [PDF]

, 2014
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza ...
Barclay, Wendy S., Bean, Thomas J., Bruce, Christine, Carroll, Miles W., Dimmock, N. J., Dove, Brian K., Dowall, Stuart, Easton, A. J. (Andrew J.), Hallis, Bassam, Marriott, Anthony C., Newman, Edmund, Pearson, Geoff, Plank, Jenna, Rayner, Emma, Ryan, Kathryn A., Silman, Nigel J., Taylor, Irene, Whittaker, Catherine J.   +17 more
core   +6 more sources

Use of a multidimensional RAPID3 questionnaire to assess the achievement of remission and minimal disease activity in patients with early psoriatic arthritis treated according to Treat-to-target strategy

Научно-практическая ревматология, 2019
The current Treat-to-target (T2T) strategy in the management of patients with psoriatic arthritis (PsA) is based on strict control over the dynamics of a patient's status and timely correction of therapy according to the presence or absence of remission ...
E. Yu. Loginova, T. V. Korotaeva, A. D. Koltakova   +2 more
doaj   +1 more source