Results 101 to 110 of about 664,402 (295)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Repairing Inconsistent XML Write-Access Control Policies

, 2007
XML access control policies involving updates may contain security flaws, here called inconsistencies, in which a forbidden operation may be simulated by performing a sequence of allowed operations. This paper investigates the problem of deciding whether
Bravo, Loreto, Cheney, James, Fundulaki, Irini   +2 more
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A Rfa1-MN-based system reveals new factors involved in the rescue of broken replication forks.

PLoS Genetics
The integrity of the replication forks is essential for an accurate and timely completion of genome duplication. However, little is known about how cells deal with broken replication forks.
Ana Amiama-Roig, Marta Barrientos-Moreno, Esther Cruz-Zambrano, Luz M López-Ruiz, Román González-Prieto, Gabriel Ríos-Orelogio, Félix Prado   +6 more
doaj   +1 more source

Twelve-years’ experience in minimal invasive Achilles tendon repair using a suture-guiding device

Journal of Orthopaedics, Trauma and Rehabilitation, 2019
Introduction: Minimal invasive Achilles tendon repair is becoming more and more popular recently. We have evaluated our results in Achilles tendon repair using minimally invasive method by a suture-guiding device.
Prisca Yeung, Lok Pong Man, Wing Hang Angela Ho   +2 more
doaj   +1 more source

Optimal maintenance strategies for systems with partial repair options and without assuming bounded costs [PDF]

, 2000
We study a repairable system with Markovian deterioration and partial repair options, carried out at fixed times $n=1,2,\ldots$ and look for optimal strategies under certain conditions. Two optimality criteria are considered: expected discounted cost and
Bruns, P.B.
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

SHARC: Space Habitat, Assembly and Repair Center [PDF]

Integrated Space Systems (ISS) has taken on the task of designing a Space Habitat, Assembly and Repair Center (SHARC) in Low Earth Orbit to meet the future needs of the space program.
Colangelo, Todd, Hoetger, Debora, Kuo, Addison, Lo, Michael, Marcus, Leland, Tran, Philip, Tutt, Chris, Wassmuth, Chad, Wildgrube, Gregory   +8 more
core   +1 more source

A bathtub pattern for repairable systems: From better-than-minimal to minimal and worse-than-minimal repairs

Proceedings of the Institution of Mechanical Engineers, Part O: Journal of Risk and Reliability
We introduce a new combined repair process to describe repairs that are initially better-than-minimal, then become minimal, before finally becoming worse-than-minimal. The extended generalized Polya process (EGPP), non-homogeneous Poisson process (NHPP), and generalized Polya process (GPP) are used to describe this repair pattern, respectively. Several
Amy Langston, Maxim Finkelstein, Ji Hwan Cha   +2 more
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source