Results 71 to 80 of about 775,328 (297)

Minimal residual disease negativity by next-generation flow cytometry is associated with improved organ response in AL amyloidosis

Blood Cancer Journal, 2021
Light chain (AL) amyloidosis is caused by a small B-cell clone producing light chains that form amyloid deposits and cause organ dysfunction. Chemotherapy aims at suppressing the production of the toxic light chain (LC) and restore organ function ...
G. Palladini, B. Paiva, A. Wechalekar, M. Massa, P. Milani, M. Lasa, S. Ravichandran, I. Krsnik, M. Basset, L. Burgos, M. Nuvolone, R. Lecumberri, A. Foli, N. Puig, M. Sesta, M. Bozzola, Pasquale Cascino, Alice Nevone, Jessica Ripepi, P. Berti, Simona Casarini, O. Annibali, A. Órfão, J. San-Miguel, G. Merlini   +24 more
semanticscholar   +1 more source

Comparison between qualitative and real-time polymerase chain reaction to evaluate minimal residual disease in children with acute lymphoblastic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2015
Introduction: Minimal residual disease is an important independent prognostic factor that can identify poor responders among patients with acute lymphoblastic leukemia.
Francisco Danilo Ferreira Paula, Silvana Maria Elói-Santos, Sandra Guerra Xavier, Mônica Aparecida Ganazza, Patricia Yoshioka Jotta, José Andrés Yunes, Marcos Borato Viana, Juliana Godoy Assumpção   +7 more
doaj   +1 more source

Prognostic role of minimal residual disease before and after hematopoietic stem cell transplantation in childhood acute lymphoblastic leukemia [PDF]

, 2015
More than 80% of children with acute lymphoblastic leukemia (ALL) can be cured through intensive and risk-oriented chemotherapy protocols. Allogeneic hematopoietic stem cell transplantation (HSCT) is considered bene\ufb01cial for approximately 10% of the
Basso, Giuseppe, Campeggio, Mimma, Fagioli, Franca, Lovisa, Federica, Magrin, Elisa, Quarello, Paola, Rossi, Bartolomeo, Rubert, Laura, Zecca, Marco   +8 more
core  

Minimal residual disease is an independent predictor for 10-year survival in CLL [PDF]

, 2016
Minimal residual disease (MRD) negativity, defined as
Abraham Varghese, Abrisqueta, Andy C. Rawstron, Bosch, Böttcher, Chi Doughty, Darren J. Newton, Dreger, Eichhorst, Fischer, Goede, Hallek, Landau, Ma, Marwan Kwok, Moreno, Moreton, Nadeu, Paul A. S. Evans, Paul Moreton, Peter Hillmen, Pettitt, Rawstron, Rawstron, Rawstron, Rossi, Santacruz, Sheila J. M. O’Connor, Strati, Thompson   +29 more
core   +1 more source

Sensitive Detection of Minimal Residual Disease in Patients Treated for Early-Stage Breast Cancer

Clinical Cancer Research, 2020
Purpose: Existing cell-free DNA (cfDNA) methods lack the sensitivity needed for detecting minimal residual disease (MRD) following therapy. We developed a test for tracking hundreds of patient-specific mutations to detect MRD with a 1,000-fold lower ...
Heather A. Parsons, J. Rhoades, S. Reed, G. Gydush, Priyanka Ram, P. Exman, Kan Xiong, Christopher C. Lo, Tianyu Li, M. Fleharty, G. Kirkner, D. Rotem, Ofir Cohen, F. Yu, Mariana Fitarelli-Kiehl, K. Leong, Melissa E Hughes, Shoshana M. Rosenberg, Laura C. Collins, K. Miller, B. Blumenstiel, L. Trippa, C. Cibulskis, D. Neuberg, M. DeFelice, Samuel Freeman, Niall J. Lennon, N. Wagle, G. Ha, D. Stover, A. Choudhury, G. Getz, E. Winer, M. Meyerson, N. Lin, I. Krop, J. C. Love, G. M. Makrigiorgos, A. Partridge, E. L. Mayer, T. Golub, V. Adalsteinsson   +41 more
semanticscholar   +1 more source

Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration

Clinical Cancer Research, 2021
The development of novel agents has transformed the treatment paradigm for multiple myeloma, with minimal residual disease (MRD) negativity now achievable across the entire disease spectrum.
K. Anderson, D. Auclair, S. Adam, A. Agarwal, Melissa Anderson, H. Avet-Loiseau, M. Bustoros, Jessica Chapman, Dana E. Connors, Ajeeta B. Dash, A. Di Bacco, Ling Du, T. Facon, J. Flores-Montero, F. Gay, I. Ghobrial, N. Gormley, I. Gupta, H. Higley, J. Hillengass, B. Kanapuru, D. Kazandjian, G. Kelloff, I. Kirsch, B. Kremer, O. Landgren, Elizabeth D Lightbody, O. Lomas, S. Lonial, M. Mateos, R. Montes de Oca, Lata Mukundan, N. Munshi, E. O’Donnell, A. Órfão, B. Paiva, Reshma Patel, Trevor J Pugh, K. Ramasamy, J. Ray, M. Roshal, J. Ross, C. Sigman, K. Thoren, S. Trudel, G. Ulaner, N. Valente, B. Weiss, E. Zamagni, Shaji K. Kumar   +49 more
semanticscholar   +1 more source

Proposal for the standardization of flow cytometry protocols to detect minimal residual disease in acute lymphoblastic leukemia

Revista Brasileira de Hematologia e Hemoterapia, 2015
Minimal residual disease is the most powerful predictor of outcome in acute leukemia and is useful in therapeutic stratification for acute lymphoblastic leukemia protocols. Nowadays, the most reliable methods for studying minimal residual disease in acute
Maura Rosane Valério Ikoma, Miriam Perlingeiro Beltrame, Silvia Inês Alejandra Cordoba Pires Ferreira, Elizabeth Xisto Souto, Mariester Malvezzi, Mihoko Yamamoto   +5 more
doaj   +1 more source

Establishment and validation of a standard protocol for the detection of minimal residual disease in B lineage childhood acute lymphoblastic leukemia by flow cytometry in a multi-center setting;

Haematologica, 2009
Minimal residual disease detection, used for clinical management of children with acute lymphoblastic leukemia, can be performed by molecular analysis of antigen-receptor gene rearrangements or by flow cytometric analysis of aberrant immunophenotypes ...
Julie Irving, Jenny Jesson, Paul Virgo, Marian Case, Lynne Minto, Lisa Eyre, Nigel Noel, Ulrika Johansson, Marion Macey, Linda Knotts, Margaret Helliwell, Paul Davies, Liam Whitby, David Barnett, Jeremy Hancock, Nick Goulden, Sarah Lawson   +16 more
doaj   +1 more source

Minimal Residual Disease Detection in Pediatric Acute Lymphoblastic Leukemia

Clinical Pediatric Hematology-Oncology, 2020
Minimal residual disease (MRD) status is the strongest independent prognostic factor for patients with pediatric acute lymphoblastic leukemia (ALL).
Miyoung Kim, Chan-Jeoung Park
doaj   +1 more source

Identifying a sufficient core group for trachoma transmission. [PDF]

, 2018
BackgroundIn many infectious diseases, a core group of individuals plays a disproportionate role in transmission. If these individuals were effectively prevented from transmitting infection, for example with a perfect vaccine, then the disease would ...
Deiner, Michael S, Keenan, Jeremy D, Lietman, Thomas M, Nash, Scott D, Oldenburg, Catherine E, Porco, Travis C   +5 more
core   +2 more sources