Results 81 to 90 of about 236,269 (292)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Minimal residual disease: premises before promises [PDF]
Minimal residual disease (MRD), a measure of residual cancer cells, is a concept increasingly employed in precision oncology, touted as a key predictive biomarker to guide treatment decisions. This paper critically analyzes the expanding role of MRD as a
core +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Minimal Residual Disease in Hematologic Disorders
Archives of Pathology & Laboratory Medicine, 1999 Abstract In almost no other area of medical oncology has the introduction of new drugs, combinations of chemotherapeutic agents, and novel biologic treatments caused such dramatic responses as it has in the treatment of malignant hematologic disorders.
S, Faderl, R, Kurzrock, Z, Estrov
openaire +2 more sources
Determination of immunoprofiles using flow cytometry in childhood acute lymphoblastic leukemia and its value regarding minimal residual disease detection [PDF]
, 2010 La Citometría de Flujo (CF) es una herramienta útil en diagnóstico y seguimiento de Leucemia Linfoblástica Aguda (LLA) en niños y los niveles de Enfermedad Mínima Residual (EMR) correlacionan con aparición de eventos adversos.
Medina Medina, Edwin Abraham
core
Haematologica, 2012 The prognostic significance of CD20 expression in acute lymphoblastic leukemia has been investigated in children and adults but is still a subject of debate.
Francesco Mannelli +21 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Minimal Residual Disease in Acute Myeloid Leukemia [PDF]
, 2014 This chapter discusses how minimal residual disease (MRD) is detected and managed in acute myeloid leukemia (AML) patients. The most commonly used techniques to detect residual leukemia in patients in complete remission (CR) are quantitative PCR (qPCR ...
Ommen, Hans Beier +9 more
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Frontiers in Oncology, 2011 Molecular detection of minimal residual disease (MRD) has become established to assess remission status and guide therapy in patients with PML-RARA+ acute promyelocytic leukemia (APL).
Jelena V Jovanovic +8 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source