Results 81 to 90 of about 6,414,902 (294)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

CD20 expression has no prognostic role in Philadelphia-negative B-precursor acute lymphoblastic leukemia: new insights from the molecular study of minimal residual disease

Haematologica, 2012
The prognostic significance of CD20 expression in acute lymphoblastic leukemia has been investigated in children and adults but is still a subject of debate.
Francesco Mannelli, Giacomo Gianfaldoni, Tamara Intermesoli, Chiara Cattaneo, Erika Borlenghi, Sergio Cortelazzo, Irene Cavattoni, Enrico Maria Pogliani, Monica Fumagalli, Emanuele Angelucci, Claudio Romani, Fabio Ciceri, Consuelo Corti, Anna Scattolin, Agostino Cortelezzi, Daniele Mattei, Ernesta Audisio, Orietta Spinelli, Elena Oldani, Alberto Bosi, Alessandro Rambaldi, Renato Bassan   +21 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Development of real-time quantitative polymerase chain reaction assays to track treatment response in retinoid resistant acute promyelocytic leukemia

Frontiers in Oncology, 2011
Molecular detection of minimal residual disease (MRD) has become established to assess remission status and guide therapy in patients with PML-RARA+ acute promyelocytic leukemia (APL).
Jelena V Jovanovic, Kristian eRennie, Dominic eCulligan, Andrew ePeniket, Anne eLennard, Justin eHarrison, Paresh eVyas, Paresh eVyas, David eGrimwade   +8 more
doaj   +1 more source

Incidence and clinical impact of sterilized disease and minimal residual disease after preoperative radiochemotherapy for rectal cancer

, 2005
In advanced rectal cancer, chemoradiation can induce downstaging until complete disappearance of the tumor or its persistence in minimal form. The complete sterilized and the minimal residual disease often are considered similar.
Bertolini F, Losi L, Santantonio M, Gavioli M, D'AMICO, Roberto, Natalini G., BERTOLINI, Federica, FALCHI, Anna Maria, LOSI, Lorena, CONTE, PIERFRANCO, Luppi G, Falchi AM, D'Amico R   +12 more
core   +1 more source

Influence of Cytokines and Autologous Lymphokine-Activated Killer Cells on Leukemic Bone Marrow Cells and Colonies in AML [PDF]

, 2001
We have already shown that cytokine cocktails (IL-1 beta, IL-3, IL-6, SCF, GM-CSF) and/or lymphokine-activated killer (LAK) cells can reduce the amounts of clonal, CD34-positive mononuclear bone marrow cells (BM-MNC) in acute myeloid leukemia (AML).
Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, Susanne Walburg   +2 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods

Haematologica, 2012
Reduction in minimal residual disease, measured by real-time quantitative PCR or flow cytometry, predicts prognosis in childhood B-cell precursor acute lymphoblastic leukemia.
Nina F. Øbro, Lars P. Ryder, Hans O. Madsen, Mette K. Andersen, Birgitte Lausen, Henrik Hasle, Kjeld Schmiegelow, Hanne V. Marquart   +7 more
doaj   +1 more source

There is nothing minimal about residual disease [PDF]

Blood, 2018
Can the detection of measurable residual disease (MRD) become the standard approach for acute lymphoblastic leukemia (ALL)? In this issue of Blood,Wood et al1 use a highly sensitive sequencing approach that is an improvement on conventional methods by both performance characteristics and potential for standardization.
openaire   +2 more sources