Results 71 to 80 of about 236,269 (292)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Minimal residual disease in breast cancer: an overview of circulating and disseminated tumour cells [PDF]

, 2016
Within the field of cancer research, focus on the study of minimal residual disease (MRD) in the context of carcinoma has grown exponentially over the past several years.
N. Jacobsen, Jacobsen, N., C. M. Saunders, Thompson, E.W., A. Tachtsidis, E. W. Thompson, Thompson, EW, Saunders, CM, McInnes, LM, Saunders, C.M., Jacobsen, N, L. M. McInnes, Tachtsidis, A, Tachtsidis, A., McInnes, L.M.   +14 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Patient-tailored analysis of minimal residual disease in acute myeloid leukemia using next generation sequencing. [PDF]

, 2016
Next generation sequencing techniques have revealed that leukemic cells in acute myeloid leukemia often are characterized by a limited number of somatic mutations. These mutations can be the basis for detection of leukemic cells in follow-up samples. The
Fogelstrand, Linda, Abrahamsson, Jonas, Samuelsson, Tore,, Pettersson, Louise,, Ståhlman, Sara, Malmberg, Erik B R, Rehammar, Anna, Palmqvist, Lars,, Rehammar, Anna,, Alm, Sofie J, Malmberg, Erik Br,, Abrahamsson, Jonas,, Kristiansson, Erik,, Samuelsson, Tore, Palmqvist, Lars, Kristiansson, Erik, Ehinger, Mats, Alm, Sofie J., Garelius, Hege, Alm, Sofie J,, Ståhlman, Sara,, Malmberg, Erik Br, Ehinger, Mats,, Garelius, Hege,, Fogelstrand, Linda,, Pettersson, Louise, St\ue5hlman, Sara   +26 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Minimal residual disease in leukaemia [Lösemilerde minimal rezidüel hastalik] [PDF]

, 2007
Relapse is still a big problem although there have been many important developments in the treatment within the last years. When the patient is hematologically and clinically in relapse and if there exist a leukaemic cell involvement in bone marrow or ...
Kömür M., Erbey F., Bayram I., Tanyeh A.   +3 more
core  

Ultrasensitive detection of acute myeloid leukemia minimal residual disease using single molecule molecular inversion probes [PDF]

, 2017
The identification of minimal residual disease is the primary diagnostic finding which predicts relapse in patients treated for acute myeloid leukemia. Ultrasensitive detection of minimal residual disease would enable better patient risk stratification ...
Stephen J. Salipante, David Wu, Adam Waalkes, Kelsi Penewit, Brent L. Wood   +4 more
core   +2 more sources

Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia

Haematologica, 2017
Outcome in childhood acute lymphoblastic leukemia is prognosticated from levels of minimal residual disease after remission induction therapy. Higher levels of minimal residual disease are associated with inferior results even with intensification of ...
Owen J. McGinn, Shekhar Krishnan, Jean-Pierre Bourquin, Puja Sapra, Clare Dempsey, Vaskar Saha, Peter L. Stern   +6 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Longitudinal tumor-informed ctDNA monitoring for recurrence and treatment response in melanoma

BMC Cancer
Background Early detection of melanoma recurrence and progression remains a clinical challenge, which relies on physical examination and imaging. Circulating tumor DNA offers a noninvasive, dynamic biomarker that may identify molecular recurrence before ...
Olivia Sleeper, Justin Fortino, Nam Woo Cho, Adil I. Daud, Katy K. Tsai, James C. Lee, Michael Alvarado, Ajay V. Maker, Lauren Liu, Christine Kim, Jason W. Chan   +10 more
doaj   +1 more source