Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
A green micro-algal growth media modified for use as a stringent minimal media for bacteria. v1 [PDF]
, 2020 Mautusi Mitra
openalex +1 more source
Becoming-interior : toward a nondual philosophy of design for dwelling-in-the-world : a thesis presented in partial fulfillment of the requirements for the degree of Master of Design at Massey University [PDF]
, 2005 Martin Heidegger suggests that dwelling is an act of inhabitation, which engenders a becoming-interior of the world. The site of this dwelling is not confined to architecture, but occurs in the space between earth and sky: the world.
Archer, Jennifer
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Negation and the Left Periphery of the Clause in Persian Yes-No Questions: A Minimalist Approach [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2017 The aim of the present paper is to analyze the negative and interrogative interpretations in the yes-no questions in Persian in terms of which verb is preposed and moved to the left periphery of the clause under the influence of discourse–functional ...
Hossein Moghani
doaj
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Studia Philosophica Estonica, 2008 My aim in this paper is to present and evaluate one version of the deflationary attitude to truth, namely the Modest Account, propounded by Wolfgang Künne in his Conceptions of Truth (OUP 2003). I introduce the deflationary theories of truth in the first
Jaan Kangilaski
doaj
FLASH FICTION IN THE WORKS OF MODERN CHILDREN’S WRITERS OF THE URALS GENRE AND STYLISTIC VARIABILITY
Филологический класс, 2018 The subject of the study is flash fiction in modern literature; the goal of the study is to identify and characterize the genre range and style features of flash fiction in the modern regional literature for children.
doaj +1 more source
The robotic future of minimally invasive cytoreduction and hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancies [PDF]
, 2023 Joanna Ortega +3 more
openalex +1 more source