Results 131 to 140 of about 217,541 (357)

A Minimalist Framework for Thought Experiment Analysis [PDF]

open access: yes, 2016
Thought experiments are frequently vague and obscure hypothetical scenarios that are difficult to assess. The paper proposes a simple model of thought experiments. In the first part, I introduce two contemporary frameworks for thought experiment analysis:
Picha, Marek
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

FLASH FICTION IN THE WORKS OF MODERN CHILDREN’S WRITERS OF THE URALS GENRE AND STYLISTIC VARIABILITY

open access: yesФилологический класс, 2018
The subject of the study is flash fiction in modern literature; the goal of the study is to identify and characterize the genre range and style features of flash fiction in the modern regional literature for children.
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Checking Mechanism in Modern Persian: A Minimalist Analysis of Case and Theta Marking [PDF]

open access: yesمطالعات زبان‌‌ها و گویش‌های غرب ایران, 2013
This study reviews and analyzes checking system in modern Persian according to Case and Theta features in Minimalist approach. In this study which is done by analytical-descriptive methods, the way structural cases such as Nominative, Accusative, Dative,
Arsalan Golfam, Maryam Najimi
doaj  

"Walking the Line": Kitsch, Class and the Morphing Subject of Value [PDF]

open access: yes, 2007
Kitsch, once reviled as the enemy of art and friend of the fascist, has recently entered a new phase of its life-course. Its appearance in art galleries and upon metropolitan sideboards has led many to conclude that taste hierarchies have been undone and

core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Minimalismo: a vueltas con el concepto de un(as) arte(s), reflexiones en torno al ciclo ¿los límites de la composición?

open access: yesBajo Palabra, 2016
La primera parte de este texto critica la intervención teórica de Michael Nyman sobre las nociones de “Minimalismo” y “música experimental”, señalando ciertas confusiones habituales.
David Díaz Soto
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy