Results 121 to 130 of about 11,183 (286)
Fragility of democratic minimalism: why the ballot is insufficient for democracy
Frontiers in Political ScienceThis paper engages Hamid's democratic minimalism which proposes democracy via ballot form is not only necessary but sufficient for democracy to flourish. Hamid proposes a state sustaining democratic norms such as voting, free elections, and protection of
Sam Mace
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Negation and the Left Periphery of the Clause in Persian Yes-No Questions: A Minimalist Approach [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2017 The aim of the present paper is to analyze the negative and interrogative interpretations in the yes-no questions in Persian in terms of which verb is preposed and moved to the left periphery of the clause under the influence of discourse–functional ...
Hossein Moghani
doaj
Archive for Rational Mechanics and Analysis, 2008 17 pages, to appear in Arch. Rational Mech.
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Studia Philosophica Estonica, 2008 My aim in this paper is to present and evaluate one version of the deflationary attitude to truth, namely the Modest Account, propounded by Wolfgang Künne in his Conceptions of Truth (OUP 2003). I introduce the deflationary theories of truth in the first
Jaan Kangilaski
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Checking Mechanism in Modern Persian: A Minimalist Analysis of Case and Theta Marking [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2013 This study reviews and analyzes checking system in modern Persian according to Case and Theta features in Minimalist approach. In this study which is done by analytical-descriptive methods, the way structural cases such as Nominative, Accusative, Dative,
Arsalan Golfam, Maryam Najimi
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source