Results 131 to 140 of about 11,183 (286)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
A Philosophical Defense of Judicial Minimalism [PDF]
, 2018 This dissertation analyzes, criticizes and ultimately defends judicial minimalism, a contemporary theory of judging that has come to the forefront of American jurisprudence in the early part of the 21st Century.
Evans, Cory A
core
Minimal models of minimal theories
Tsukuba Journal of Mathematics, 1993 The author proves that a first-order theory, \(T\), has \(2^{\aleph_ 0}\) minimal models, if it is stable and trivial, and if it has a minimal and non-prime model in which each element has Lascar rank \(\leq 1\). This result is valid for any language in contrast to Marcus's and Toffalori's works that consider the language with one unary function [cf ...
openaire +3 more sources
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Technological Minimalism versus Second Life
This chapter addresses a certain resistance against the use of Second Life in education, which is based on the theory of technological minimalism. The main arguments behind this resistance and the theory’s basic concepts are discussed. Then a critique of
Joao Mattar
core +1 more source
Living simply: embracing minimalism [PDF]
Minimalism appears as a ray of simplicity and peace in the middle of chaos in today's busy society. It promotes deliberate simplification in many facets of life to cultivate gratitude, satisfaction, and congruence with one's own ideals.
CEBOTARI, Daniela +3 more
core +1 more source
Bajo Palabra, 2016 La primera parte de este texto critica la intervención teórica de Michael Nyman sobre las nociones de “Minimalismo” y “música experimental”, señalando ciertas confusiones habituales.
David Díaz Soto
doaj
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source