Results 71 to 80 of about 224,088 (359)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Language, Thought, and Culture: Views and Arguments [PDF]

open access: yesTaḥqīqāt-i Farhangī-i Īrān, 2009
This study follows two aims: one to review some late views on the relations among language, thought, and culture; and the other, to offer a new strategy, in a novel model, based on last achievements in the minimalist approach.
Keyvan Zahedi
doaj   +1 more source

Minimal charts

open access: yesTopology and its Applications, 2018
In this paper, we give definitions of three kinds of minimal charts, and we investigate properties of minimal charts and establish fundamental theorems characterizing minimal charts. To classify charts with two or three crossings we use the fundamental theorems. In the future paper, we give an numeration of the charts with two crossings.
Nagase, Teruo, Shima, Akiko
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Digital Digital Minimalism: Paradigma Baru Pencegahaacn Adiksi Internet pada Generasi Z

open access: yesJurnal Ilmiah Bimbingan Konseling Undiksha
Penggunaan internet yang berlebihan dapat mengganggu keseimbangan hidup, mempengaruhi kesehatan mental, dan mengurangi produktivitas. Oleh karena itu, penelitian ini bertujuan untuk mengeksplorasi penerapan digital minimalism sebagai solusi efektif ...
Fadillatul Nisa, Wahidah Fitriani
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Exploring the Effect of Minimalism on Ethical Consumer Behavior: A Value–Identity–Personal Norm Theory Approach

open access: yesAdministrative Sciences
This study investigates the impact of minimalism on ethical consumption within the framework of the Value–Identity–Personal Norms (VIP) model. Data were collected from 340 Turkish consumers using a convenience sampling method and an online survey ...
Müzeyyen Gelibolu, Kamel Mouloudj
doaj   +1 more source

Which values should be built into economic measures? [PDF]

open access: yes, 2019
Many economic measures are structured to reflect ethical values. I describe three attitudes towards this: maximalism, according to which we should aim to build all relevant values into measures; minimalism, according to which we should aim to keep values
Schroeder, S. Andrew
core  

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