Results 101 to 110 of about 366,214 (267)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Combined vitamin K2 and D3 therapy improves endoscopic fusion outcomes in osteoporotic lumbar degenerative disease: a prospective study

Scientific Reports
The efficacy of combined vitamin K2 and D3 therapy on bone fusion outcomes following endoscopic lumbar surgery in osteoporotic patients remains unclear.
Yanan Wang, Yidi Wang, Fengming Wang, Zhenyu Wang, Ran Sun, Xiaoling Huang, Song Fu   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Minimally invasive surgery for Achilles tendon pathologies

, 2010
Nicola Maffulli1, Umile Giuseppe Longo2, Filippo Spiezia2, Vincenzo Denaro21Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, London, England; 2Department of Orthopedic and Trauma Surgery, Campus Bio-Medico ...
Nicola Maffulli, Umile Giuseppe Longo, et al, Filippo Spiezia   +3 more
core  

Bone mesenchymal stem cells based on matric hydrogels attenuate intervertebral disc degeneration by suppressing oxidative stress-induced ferroptosis

Scientific Reports
Intervertebral disc degeneration (IVDD) and its attendant lower back pain are a major medical challenge. Ferroptosis has become a new target for the treatment of IVDD. Mesenchymal stem cells (MSCs) are a promising regenerative therapy for IVDD.
Song Fu, Renhua Lv, Longqiang Wang, Zhenyu Wang, Fengming Wang, Hao Gao, Wei Zhao, Xiaoling Huang, Xiaojun Li, Yanan Wang   +9 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Minimally invasive excision of aortic valve fibroelastoma

, 2016
Papillary fibroelastoma is a rare primary tumor of cardiac origin accounting for approximately 7.9–10.0 % of all primary cardiac neoplasms. Due to high risk of fragmentation and thromboembolic complications emergency surgical excision is a standard of ...
B.М. Тоdurov, G.I. Darvish, M.D. Glagola, O.G. Bitsadze, S.I. Dorofeeva, А.V. Ivanyuk, N.V. Shatelen, O.S. Bolgova   +7 more
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Endoscopic 3 DoF-Instrument with 7 DoF Force/Torque Feedback

, 2009
Minimally invasive surgery (as previously discussed) is an operation technique advantageous for patients. However, surgeons have to contend with a number of disadvantages.
Thielmann, Sophie, Hirzinger, Gerd, Seibold, Ulrich, Kübler, Bernhard   +3 more
core