Results 81 to 90 of about 1,080,179 (309)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Endoscopic 3 DoF-Instrument with 7 DoF Force/Torque Feedback [PDF]

, 2009
Minimally invasive surgery (as previously discussed) is an operation technique advantageous for patients. However, surgeons have to contend with a number of disadvantages.
Thielmann, Sophie, Hirzinger, Gerd, Seibold, Ulrich, Kübler, Bernhard   +3 more
core  

Minimally Invasive Computer-Assisted Stereotactic Fenestration of an Aqueductal Cyst: Case Report

, 2010
Introduction: Current advances in frame modeling and computer software allow stereotactic procedures to be performed with great accuracy and minimal risk of neural tissue or vascular injury. Case Report: In this report we associate a previously described
GENTIL, A. F., FONOFF, E. T., PADILHA, P. M., TEIXEIRA, M. J.   +3 more
core   +1 more source

Minimally Invasive Lateral Access Corpectomy for a Solitary Renal Cell Carcinoma Spinal Metastasis: A Case Report

, 2021
10.21182/jmisst.2018.00360Journal of Minimally Invasive Spine Surgery and Technique3270 ...
Hung, Wu Pang, Zhao Jie, Joel Lee, Gamaliel, Tan Yu Heng   +2 more
core   +1 more source

Application of unilateral biportal endoscopy technique to resect a thoracic spinal intradural extramedullary meningioma: technical report and review of the literature

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Background Meningiomas are common intradural extramedullary spinal tumors, which arise from arachnoid cap cells in the leptomeninges surrounding the brain or spinal cord.
Rongxue Shao, Wei Cheng, Wei Zhang, Jiaming Liang, Liqi Ruan, Chengyue Zhu, Hao Pan   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Soft skills during residency in Spain: an analysis of the specialized training programmes

BMC Medical Education
Background In recent years, the importance of soft skills in reducing errors and consequently improving clinical practice has become increasingly evident. Residents should be trained in these skills during their specialised training.
Luisa F. Sánchez-Peralta, J. Blas Pagador, Francisco M. Sánchez Margallo   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Editor’s Pick: Recent Developments in Minimally Invasive Radical Prostatectomy [PDF]

, 2015
Minimally invasive surgery has gained a dominant status in prostate cancer surgery during the last decade. The benefits of minimally invasive prostatectomy were demonstrated by pioneers of conventional laparoscopic prostatectomy, however, the real ...
Antti Kaipia, Jarno Riikonen
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source