Results 71 to 80 of about 525,166 (307)

Higher osimertinib introduction rate achieved by multiple repeated rebiopsy after acquired resistance to first/second generation EGFR‐TKIs

open access: yesThoracic Cancer, 2021
Background Indication for treatment with osimertinib after first/second generation (1/2G) epidermal growth factor receptor‐tyrosine kinase inhibitor (EGFR‐TKI) resistance depends on T790M mutation detected by rebiopsy. The aim of our study was to analyze
Taira Ninomaru   +5 more
doaj   +1 more source

Combined laparoscopic pyelolithotomy and endoscopic pyelolithotripsy for staghorn calculi. Long-term follow-up results from a case series [PDF]

open access: yes, 2015
Purpose: Staghorn renal stones are a challenging field in urology. Due to their high recurrence rates, particularly those associated with an infective process, a complete removal is the ultimate goal in their management.
AL SALHI, Yazan   +9 more
core   +1 more source

Minimally Invasive Stomas [PDF]

open access: yesClinics in Colon and Rectal Surgery, 2008
Traditionally, stoma creation and end stoma reversal have been performed via a laparotomy incision. However, in many situations, stoma construction may be safely performed in a minimally invasive nature. This may include a trephine, laparoscopic, or combined approach. Furthermore, Hartmann's colostomy reversal, a procedure traditionally associated with
Michael D, Hellinger   +1 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Minimally invasive aortic valve surgery [PDF]

open access: yes, 2016
Aortic valve disease is a prevalent disorder that affects approximately 2% of the general adult population. Surgical aortic valve replacement is the gold standard treatment for symptomatic patients.
Bertolino, E.   +8 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

New tracheal stainless steel stent pilot study: twelve month follow-up in a rabbit model [PDF]

open access: yesPeerJ, 2019
Background Canine tracheal collapse is a complex airway pathology without promising treatment results. Currently nitinol stents are the best surgical option; however, some professionals are doubting if stent placement is the best option due to the ...
Sandra Lopez-Minguez   +5 more
doaj   +2 more sources

Advances in general surgical laparoscopy [PDF]

open access: yes, 2013
Minimally invasive surgery has been with us for the past century. The lasl thirty years have seen an exponential growth in the development of laparoscopic techniques which allow major surgery to be performed through smaller incisions and less ...
Abela, Jo Etienne
core  

Liver Abscesses: a 10-year Vinnytsya University Study [PDF]

open access: yes, 2020
According to MEDLINE database there were about 1278 papers on liver abscess published in a period from 2001 to 2015.The aim of the study is to improve liver abscess treatment results comparing minimally invasive and traditional operative techniques ...
Makarov, V. (Viktor)   +4 more
core  

Stereotactic guidance for navigated percutaneous sacroiliac joint fusion. [PDF]

open access: yes, 2015
Arthrodesis of the sacroiliac joint (SIJ) for surgical treatment of SIJ dysfunction has regained interest among spine specialists. Current techniques described in the literature most often utilize intraoperative fluoroscopy to aid in implant placement ...
Kim, Kee D   +4 more
core   +1 more source

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