Results 111 to 120 of about 5,740,582 (295)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Minimizing the Side Effect of Cost-saving Build Selection in Continuous Integration
, 2020 Data set on Minimizing the Side Effect of Cost-saving Build Selection in Continuous ...
Servant, Francisco, Jin, Xianhao
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Dynamics of globally minimizing orbits in contact Hamiltonian systems [PDF]
In this paper, we study the asymptotic behavior of globally minimizing orbits of contact Hamiltonian systems. Under some assumptions, we prove that the $ω$-limit set of globally minimizing orbits is contained in the set of semi-static ...
Xu, Yang, Zhao, Kai, Yan, Jun
core +1 more source
On the enumeration of minimal covers and minimal forbidden sets
, 2002 An independence system is a family I of subsets of a ground set V with the property that any subset of any member of I also belongs to I. The inclusion-minimal sets not in I are called minimal covers. We prove several complexity results related to computation, enumeration, and counting of the minimal covers of an independence system.
Stork F., Uetz M.
openaire +2 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
On the minimal covering of infinite sets
Discrete Applied Mathematics, 1993 It is characterized when a set system \({\mathcal F}\) has a well-ordering such that every point of \(\cup{\mathcal F}\) has a last member of which it is an element. If this holds, then there is a subfamily which is a minimal cover of \(\cup{\mathcal F}\). Another condition for the existence of a minimal cover is given.
openaire +1 more source
Minimizing the Expected Market Time to Reach a Certain Wealth Level [PDF]
In a financial market model, we consider variations of the problem of minimizing the expected time to upcross a certain wealth level. For exponential Levy markets, we show the asymptotic optimality of the growth-optimal portfolio for the above problem ...
Constantinos Kardaras, Eckhard Platen
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source