Results 81 to 90 of about 5,740,582 (295)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Regularity of area minimizing currents mod p [PDF]
, 2020 We establish a first general partial regularity theorem for area minimizing currents mod(p), for every p, in any dimension and codimension. More precisely, we prove that the Hausdorff dimension of the interior singular set of an m-dimensional area ...
De Lellis C +3 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Convexity and minimal Gerschgorin sets [PDF]
Proceedings of the American Mathematical Society, 1968 1. The Gerschgorin circle theorem gives bounds for the eigenvalues of an n X n comiplex matrix A = (aij) in terms of the diagonal elements and the moduli of the off-diagonal elements. Thus these bounds apply equally well to any matrix in the class (1) OA = = (bij) j b,ii = aj,,, I bi,j = | aIj , 1 -< i,j < n} .
openaire +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
On the uniqueness of energy-minimizing curves in constrained spaces [PDF]
, 2023 In this paper, we investigate energy-minimizing curves with fixed endpoints $p$ and $q$ in a constrained space. We prove that when one of the endpoints, say $p$, is fixed, the set of points $q$ for which the energy-minimizing curve is not unique has no ...
Lee, Ki-Ahm, Lee, Taehun
core +1 more source
Stable Zero Lagrange Duality for DC Conic Programming
Journal of Applied Mathematics, 2012 We consider the problems of minimizing a DC function under a cone-convex constraint and a set constraint. By using the infimal convolution of the conjugate functions, we present a new constraint qualification which completely characterizes the Farkas ...
D. H. Fang
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Solving Flexible Job Shop Scheduling with Multi Objective Approach
International Journal of Industrial Engineering and Production Research, 2010 In this paper flexible job-shop scheduling problem (FJSP) is studied in the case of optimizing different contradictory objectives consisting of: (1) minimizing makespan, (2) minimizing total workload, and (3) minimizing workload of the most loaded ...
Arash Motaghedi-larijani +2 more
doaj
MODEL OF THE OPTIMAL DISTRIBUTION OF THE SET OF PROJECT TASKS
Вісник Національного технічного університету «ХПÌ». Серія: Стратегічне управління, управління портфелями, програмами та проектами, 2015 There have been proposed the description of the mathematical model of the distribution of a set of tasks separate project, which is part of the program, to determine the optimal sequence of tasks to ensure that all the restrictions imposed on the timing ...
Геннадий Николаевич ГЛУХОВ +3 more
doaj +1 more source