Results 111 to 120 of about 16,408 (292)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Blocked Regular Fractional Factorial Designs With Minimum Aberration [PDF]
, 2011 This paper considers the construction of minimum aberration (MA) blocked factorial designs. Based on coding theory, the concept of minimum moment aberration due to Xu (2003) for unblocked designs is extended to blocked designs. The coding theory approach
Hongquan Xu
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Generalized Minimum Aberration mixed-level orthogonal arrays: a general approach based on sequential integer quadratically constrained quadratic programming [PDF]
, 2017 Orthogonal Fractional Factorial Designs and in particular Orthogonal Arrays are frequently used in many fields of application, including medicine, engineering and agriculture.
Fontana, Roberto
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
J2 optimality and Multi-level Minimum Aberration Criteria in fractional factorial design
, 2012 The desirable properties of fractional factorial design: Balance and orthogonal; was examined for near balance and near orthogonal using the balance coefficient and J2 optimality criteria respectively.
I.S., Salawu, +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Maximal rank minimum aberration and doubling
Chen and Cheng [Chen, H., Cheng, C.-S., 2006. Doubling and projection: A method of constructing two-level designs of resolution IV. Ann. Statist. 34, 546-558] discussed the method of doubling for constructing two-level regular designs of resolution IV ...
Zhang, Runchu, Hu, Jianwei
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