Results 51 to 60 of about 16,408 (292)

Design of an objective lens with a minimum chromatic aberration coefficient

open access: yesMicroscopy and Microanalysis, 1997
Abstract The Schelzer resolution is defined as the highest spatial frequency which is transferred into the image with the same phase as all lower frequencies. The resolution of the information limit is, however, determined by the information from the specimen which is equal to the degree of noise. The Schelzer resolution is determined by
K Tsuno, D A Jefferson
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

DoE.MIParray: An R Package for Algorithmic Creation of Orthogonal Arrays

open access: yesJournal of Open Research Software, 2020
The R package DoE.MIParray uses mixed integer optimization for creating well-balanced arrays for experimental designs. Its use requires availability of at least one of the commercial optimizers Gurobi or Mosek.
Ulrike Grömping
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Clinical Outcomes Comparison of Combined Small Incision Lenticule Extraction with Collagen Cross-Linking Versus Small Incision Lenticule Extraction Only

open access: yesJournal of Ophthalmology, 2022
Purpose. To evaluate clinical outcome during 24 months follow-up between small incision lenticule extraction combined with cross-linking (SMILE Xtra) and small incision lenticule extraction (SMILE) only. Setting.
Ayoub Chabib   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

CYTOLOGICAL STUDIES OF THE MEIOSIS BEHAVIOUR DIVISION OF (DATURA, ERUCA AND CARDUUS) PLANTS IN HABANIA LAKE OF ANBAR [PDF]

open access: yesمجلة جامعة الانبار للعلوم الصرفة, 2012
During the study of the behavior of meiosis in 5 anthers in each species of (Datura inoxia(Solanaceae),Eruca sativa(Cruciferae)andCarduus pycnocephalus(Compositae) around the area of Habania leak, Datura plant revealed a moderate number of cells between (
NAJI SWADI NASSER, ENAS ADNIN MANFY
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Materials News: Interfacial chemistry and atomic arrangement of ZrO2 − La2/3Sr1/3MnO3 pillar-matrix structures

open access: yesAPL Materials, 2014
We studied ZrO2 − La2/3Sr1/3MnO3 pillar–matrix thin films which were found to show anomalous magnetic and electron transport properties. With the application of an aberration-corrected transmission electron microscope, interfacial chemistry, and atomic ...
Dan Zhou   +6 more
doaj   +1 more source

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