Results 71 to 80 of about 16,408 (292)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Minimum moment aberration for nonregular designs and supersaturated designs [PDF]
, 2001 Nonregular designs are used widely in experiments due to their run size economy and flexibility. These designs include the Plackett-Burman designs and many other symmetrical and asymmetrical orthogonal arrays.
Xu, Hongquan
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Generalised minimum aberration construction results for symmetrical orthogonal arrays
Generalised minimum aberration is a recently-established design criterion for the whole class of orthogonal arrays and fractional factorial designs. The criterion is, as its name suggests, a generalisation of minimum aberration for regular designs and of
Neil A. Butler
core +1 more source
Interaction balance for symmetrical factorial designs with generalized minimum aberration
, 2006 Primary 62K15, Secondary 62K05, Coding theory, Fractional factorial design, Generalized minimum aberration, Generalized wordlength pattern, Interaction balance, Nonregular, Symmetrical,
He, SY, Mingyao Ai, Shuyuan He, Ai, MY
core +1 more source
Zernike Polynomiales· for Opticl Ssytew. With Borizantal Recta_nguJar Aperture
Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017 For small aberrations, the ·suehl' ratio of an . im i'ng syStem • depends on trne aberration v·ariance. Its· aberration fu.nct1on ·is e:qJanded in terms 9f-l nike polynomials. which are_ oirrh6goilal over a circular apeltitte.
A, ,1J. AL-.llamdani, 8 Y. RAI-As di
doaj
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source