Results 111 to 120 of about 440,166 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Investigations of Antibacterial Activity of Methanol and Aqueous Ex-tracts of the Body Wall of Sea Cucumber Holothuria leucospilota on some Human Pathogenic Bacteria

پزشکی بالینی ابن سینا, 2016
Introduction & Objective: Holothuria leucospilota, sea cucumber, is a species of the Phylum Echinodermata. Sea cucumbers have the most natural products with biological activity.
M. Nazemi, Y. Moradi, M. Gozari, F. Legzaee, M. Karimpour   +4 more
doaj  

Antimicrobial activities of Gold nanoparticles against Salmonella typhimurium [PDF]

, 2016
Background and aims: One of the major problems in hospitals is resistant pathogenic bacteria to antimicrobial substances. The problem of increased costs of treatment failure and mortality rates is increasing.
Ghanavati Behbahan, Farzaneh., Mousavi, Seyedeh Razieh., Rezaei, Razieh., Salari, Mohammad.   +3 more
core  

minimum inhibitory concentration

Citation: 'minimum inhibitory concentration' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15211 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Antimicrobial activity of a selection of organic acids, their salts and essential oils against swine enteropathogenic bacteria

Porcine Health Management, 2019
Background Accurate screening of new alternative antimicrobial compounds is essential for their use to control pathogens in swine production due to the replacement of antibiotics and zinc oxide.
Manuel Gómez-García, Cinta Sol, Pedro J. G. de Nova, Mónica Puyalto, Luis Mesas, Héctor Puente, Óscar Mencía-Ares, Rubén Miranda, Héctor Argüello, Pedro Rubio, Ana Carvajal   +10 more
doaj   +1 more source

The Test Activities Antibacterials Seaweed Extract (Eucheuma Cottonii) Against Bacteria Staphylococcus Aureus and Bacteria Escherichia Coli [PDF]

, 2017
Eucheuma cottonii seaweed is one of the plants that have bioactive compounds that can produce secondary metabolites that act as antibacterial, antioxidant, anticoagulant.
Megawati, M. (Megawati), Sari, N. I. (N), Sukmiwati, M. (Mery)   +2 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Antibacterial activities of Origanum vulgare alone and in combination with different antimicrobials against clinical isolates of Salmonella typhi

Ancient Science of Life, 2013
Background: Typhoid fever continues to remain a major public health problem especially in the areas where there is problem of sanitation and hygiene.
Veni Bharti, Neeru Vasudeva, Sunil Sharma, Joginder Singh Duhan   +3 more
doaj   +1 more source