Results 81 to 90 of about 933,956 (306)

Shifting relative importance of climatic constraints on land surface phenology

Environmental Research Letters, 2018
Land surface phenology (LSP), the study of seasonal dynamics of vegetated land surfaces from remote sensing, is a key indicator of global change, that both responds to and influences weather and climate.
Irene Garonna, Rogier de Jong, Reto Stöckli, Bernhard Schmid, David Schenkel, David Schimel, Michael E Schaepman   +6 more
doaj   +1 more source

Changing Trends and Abrupt Features of Extreme Temperature in Mainland China from 1960 to 2010

Atmosphere, 2016
Studies based on the 10th (90th) percentiles as thresholds have been presented to assess moderate extremes in China and globally. However, there has been notably little research on the occurrences of high extremes of warm days and hot days (TX95p and ...
Shibo Fang, Yue Qi, Guojun Han, Qingxiang Li, Guangsheng Zhou   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Monthly minimum upstream temperature (average)

, 2015
Monthly minimum upstream temperature ...
Sami Domisch (3317064), Walter Jetz (175506), Domisch, Sami, Giuseppe Amatulli (3317067), Jetz, Walter, Amatulli, Giuseppe   +5 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Projections of Temperature and Precipitation Changes under CMIP6 Scenarios in Sistan-va-Baluchestan Province [PDF]

مجله آب و خاک
Introduction The 21st century is witnessing the increase of climate change as an important challenge due to its destructive environmental and socio-economic effects. Extreme climatic conditions have become frequent and more intense in recent decades as a
S. Mirshekari, F. Yaghoubi, S.A. Hashemi
doaj   +1 more source

Minimum maximum temperature gradient coil design [PDF]

Magnetic Resonance in Medicine, 2012
Ohmic heating is a serious problem in gradient coil operation. A method is presented for redesigning cylindrical gradient coils to operate at minimum peak temperature, while maintaining field homogeneity and coil performance. To generate these minimaxT coil windings, an existing analytic method for simulating the spatial temperature distribution of ...
While, Peter T., Poole, Michael S., Forbes, Larry K., Crozier, Stuart   +3 more
openaire   +5 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Effects of Meteorological Factors and Frost Injury on Flowering Stage of Apples and Pears Across Regions at Varying Altitudes

Horticulturae
Recent meteorological variability in winter and spring complicates predicting and managing frost damage in apples and pears. This study investigated the relationship between frost injury during the flowering stages of apples (‘Hongro’ and ‘Fuji’) and ...
Young-Min Choi, Sang-Baek Kim, Dong-Geun Choi, Seung-Heui Kim, Ju-Hee Song   +4 more
doaj   +1 more source