Results 71 to 80 of about 2,710,081 (306)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Shifting relative importance of climatic constraints on land surface phenology

Environmental Research Letters, 2018
Land surface phenology (LSP), the study of seasonal dynamics of vegetated land surfaces from remote sensing, is a key indicator of global change, that both responds to and influences weather and climate.
Irene Garonna, Rogier de Jong, Reto Stöckli, Bernhard Schmid, David Schenkel, David Schimel, Michael E Schaepman   +6 more
doaj   +1 more source

Lifted temperature minimum during the atmospheric evening transition [PDF]

Atmospheric Chemistry and Physics, 2014
Abstract. Observations of lifted temperature minimum (LTM) profiles in the nocturnal boundary layer were first reported in 1932. It was defined by the existence of a temperature minimum some centimetres above the ground. During the following decades, several research studies analysed this phenomenon verifying its existence and postulating different ...
E. Blay-Carreras, E. R. Pardyjak, D. Pino, S. W. Hoch, J. Cuxart, D. Martínez, J. Reuder   +6 more
openaire   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Precise Determination of Minimum Achievable Temperature for Solid-State Optical Refrigeration

, 2012
We measure the minimum achievable temperature (MAT) as a function of excitation wavelength in anti-Stokes fluorescence cooling of high purity Yb3+-doped LiYF4 (Yb:YLF) crystal.
Di Lieto, Alberto, Epstein, Richard I., Melgaard, Seth D., Seletskiy, Denis V., Sheik-Bahae, Mansoor, Tonelli, Mauro   +5 more
core   +1 more source

Turbulent thermal diffusion of aerosols in geophysics and laboratory experiments [PDF]

, 2004
We discuss a new phenomenon of turbulent thermal diffusion associated with turbulent transport of aerosols in the atmosphere and in laboratory experiments.
Buchholz, J., Eidelman, A., Elperin, T., Gruenefeld, G., Kleeorin, N., Krein, A., Rogachevskii, I.   +6 more
core   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Projections of Temperature and Precipitation Changes under CMIP6 Scenarios in Sistan-va-Baluchestan Province [PDF]

مجله آب و خاک
Introduction The 21st century is witnessing the increase of climate change as an important challenge due to its destructive environmental and socio-economic effects. Extreme climatic conditions have become frequent and more intense in recent decades as a
S. Mirshekari, F. Yaghoubi, S.A. Hashemi
doaj   +1 more source

Quantitative measurements of the thermopower of Andreev interferometers

, 2001
Using a new second derivative technique and thermometers which enable us to determine the local electron temperature in a mesoscopic metallic sample, we have obtained quantitative measurements of the low temperature field and temperature dependent ...
Andreev A. F., Black M. J., D. A Dikin, Dikin D. A., Eom J., Parsons A., S Jung, V Chandrasekhar, van Harlingen D. J., Wilhelm F. K.   +9 more
core   +1 more source

Climate Variability and Ross River Virus Transmission in Townsville Region, Australia 1985 to 1996 [PDF]

, 2004
Background How climate variability affects the transmission of infectious diseases at a regional level remains unclear. In this paper, we assessed the impact of climate variation on the Ross River virus (RRv) transmission in the Townsville region ...
A. J. McMichael, Aaskov JG, Allard R, Australian Bureau of Statistics, Bowie C, Catalano R, Chatfield C, Checkley W, Curran M, Curriero FC, Doherty RL, Helfenstein U, Helfenstein U, Helfenstein U, Hennessy KJ, Kay BH, Liehne PF, Lindsay M, Lindsay MD, Lindsay MD, Mackenzie JS, McManus TJ, McMichael AJ, Nimmol JR, Russell RC, Shilu Tong, Shope RE, Tabachnick BG, Tong SL, Weinstein P, Wenbiao Hu, Whetton P   +31 more
core   +2 more sources