Results 11 to 20 of about 30,696 (201)

Minocycline and antipsychotics inhibit inflammatory responses in BV-2 microglia activated by LPS via regulating the MAPKs/ JAK-STAT signaling pathway

BMC Psychiatry, 2023
Background Abnormal activation of microglia is involved in the pathogenesis of schizophrenia. Minocycline and antipsychotics have been reported to be effective in inhibiting the activation of microglia and thus alleviating the negative symptoms of ...
Yujun Long, Ying Wang, Yidong Shen, Jing Huang, Yamin Li, Renrong Wu, Jingping Zhao   +6 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation

Molecular Pain, 2012
Background Minocycline prevents the development of neuropathic and inflammatory pain by inhibiting microglial activation and postsynaptic currents. But, how minocycline obviates acute visceral pain is unclear.
Cho Ik-Hyun, Lee Min Jung, Jang Minhee, Gwak Nam Gil, Lee Ka Yeon, Jung Hyuk-Sang   +5 more
doaj   +1 more source

Analgesic and anti-inflammatory effects of minocycline in chicks [PDF]

Iraqi Journal of Veterinary Sciences
Minocycline is a second-generation tetracycline that has a variety of nonantimicrobial properties. This study aimed to assess the analgesic and anti-inflammatory activities of minocycline in chicks.
Yasser M. Albadrany, Ahmed S. Naser, Khalid A. Shaaban   +2 more
doaj   +1 more source

Better together? Treating traumatic brain injury with minocycline plus N-acetylcysteine

Neural Regeneration Research, 2022
Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many hours, thus only delayed damage can be ...
Siobhán Lawless, Peter J Bergold
doaj   +1 more source

Re-evaluation of mitochondrial permeability transition as a primary neuroprotective target of minocycline

Neurobiology of Disease, 2007
Minocycline has been shown to be neuroprotective in ischemic and neurodegenerative disease models and could potentially be relevant for clinical use.
Roland Månsson, Magnus J. Hansson, Saori Morota, Hiroyuki Uchino, Christine T. Ekdahl, Eskil Elmér   +5 more
doaj   +1 more source

Minocycline in phenotypic models of Huntington's disease

Neurobiology of Disease, 2005
Minocycline has been shown to be neuroprotective in various models of neurodegenerative diseases. However, its potential in Huntington's disease (HD) models characterized by calpain-dependent degeneration and inflammation has not been investigated. Here,
Kadiombo Bantubungi, Carine Jacquard, Anita Greco, Annita Pintor, Abdelwahed Chtarto, Khalid Tai, Marie-Christine Galas, Liliane Tenenbaum, Nicole Déglon, Patrizia Popoli, Luisa Minghetti, Emmanuel Brouillet, Jacques Brotchi, Marc Levivier, Serge N. Schiffmann, David Blum   +15 more
doaj   +1 more source

When Antibiotics Leave a Mark: Minocycline-Induced Hyperpigmentation. [PDF]

Clin Case Rep
Bluish discoloration of the dorsal aspects of the hands and nails. ABSTRACT This article presents two patients with significant minocycline‐induced hyperpigmentation, illustrating the diverse clinical manifestations across various body sites. Judicious use of minocycline and early recognition of its adverse effects are crucial to reduce the risk of ...
Ting C, Daniel BS, O'Brien T, Robinson AJ.   +3 more
europepmc   +2 more sources

Minocycline-based therapy for carbapenem-resistant Acinetobacter baumannii pneumonia: A multicenter retrospective study

International Journal of Infectious Diseases
Background: Minocycline is one of the few antibiotics that remain highly effective against carbapenem-resistant Acinetobacter baumannii (CRAB). However, the efficacy of minocycline for treating CRAB pneumonia has not been clearly demonstrated yet ...
Hyeri Seok, Si-Ho Kim, Hye Jin Shi, Won Suk Choi, Dae Won Park, Yu Mi Wi, Cheon-Hoo Jeon, Yoonseon Park, Shin Hee Hong, Kyungmin Huh   +9 more
doaj   +1 more source

Anti-apoptotic effects of minocycline on doxorubicin-induced cardiotoxicity in male Wistar rats [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان, 2023
Background and Aim: Doxorubicin is an effective chemotherapeutic agent. However, use of this drug is limited due to its dose-dependent cardiotoxicity. Activation of apoptotic pathways in myocardial tissue plays an important role in doxorubicin- induced ...
Hossein Piri, Ehsan Aali, Samaneh Keshavarz Hedayati, Sanaz Keshavarz Shahbaz, Yazdan Naderi   +4 more
doaj