Results 21 to 30 of about 30,696 (201)

Minocycline intra-bacterial pharmacokinetic hysteresis as a basis for pharmacologic memory and a backbone for once-a-week pan-tuberculosis therapy

Frontiers in Pharmacology, 2022
Background: There is need for shorter duration regimens for the treatment of tuberculosis, that can treat patients regardless of multidrug resistance status (pan-tuberculosis).Methods: We combined minocycline with tedizolid, moxifloxacin, and rifampin ...
Devyani Deshpande, Shashikant Srivastava, Jotam Garaimunashe Pasipanodya, Tawanda Gumbo, Tawanda Gumbo   +4 more
doaj   +1 more source

Diffuse skin hyperpigmentation associated with chronic minocycline use in a patient with prosthetic joint infection

IDCases, 2017
Cutaneous hyperpigmentation is a recognized adverse effect of chronic minocycline use occurring in up to 50% of patients. In this report we present a rare case of extensive skin hyperpigmentation involving both lower extremities in a patient receiving ...
Hadi Berbari, Elie F. Berbari, Irene G. Sia   +2 more
doaj   +1 more source

Minocycline Nanocrystals: A New Approach for Treating Acne with Reduced Systemic Side Effects

Pharmaceutics
Background/Objectives: Acne vulgaris is a chronic skin infection characterized by high sebum secretion, keratosis around hair follicles, inflammation, and imbalance in androgen levels. Acne vulgaris causes permanent scars or skin pigmentation in cases of
Suha M. Abudoleh, Juhaina M. Abu Ershaid, Dima Lafi, Nisreen A. Dahshan, Ahmad Talhouni, Amjad Abuirmeileh   +5 more
doaj   +1 more source

Minocycline-induced transient depersonalization: A case report

SAGE Open Medical Case Reports, 2019
Minocycline is a medication commonly used for the treatment of acne vulgaris. The central nervous system-induced side effects of minocycline include headaches, pseudotumor cerebri, ataxia, and vestibular dysfunction. Many minocycline-related side effects
Yassein Shamout, Alissa Sigal, Ivan V Litvinov   +2 more
doaj   +1 more source

Minocycline decreases CCR2-positive monocytes in the retina and ameliorates photoreceptor degeneration in a mouse model of retinitis pigmentosa.

PLoS ONE, 2021
Retinal inflammation accelerates photoreceptor cell death caused by retinal degeneration. Minocycline, a semisynthetic broad-spectrum tetracycline antibiotic, has been previously reported to rescue photoreceptor cell death in retinal degeneration.
Ryo Terauchi, Hideo Kohno, Sumiko Watanabe, Saburo Saito, Akira Watanabe, Tadashi Nakano   +5 more
doaj   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Minocycline for Controlling Neuropathic Pain: A Systematic Narrative Review of Studies in Humans

Journal of Pain Research, 2021
Dong Ah Shin,1 Tae Uk Kim,2 Min Cheol Chang3 1Department of Neurosurgery, Yonsei University, College of Medicine, Seoul, Republic of Korea; 2Department of Physical Medicine and Rehabilitation, College of Medicine, Dankook University, Cheonan, Republic of
Shin DA, Kim TU, Chang MC
doaj  

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

The Microglial Activation Inhibitor Minocycline, Used Alone and in Combination with Duloxetine, Attenuates Pain Caused by Oxaliplatin in Mice

Molecules, 2021
The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available analgesics, and novel mechanism-based therapies are being evaluated for this debilitating condition.
Kinga Sałat, Anna Furgała-Wojas, Robert Sałat   +2 more
doaj   +1 more source