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Minor histocompatibility antigens
Current Opinion in Immunology, 1997The existence of transplantation antigens, in addition to those encoded by genes in the MHC, has been known for over half a century. The molecular identification of these additional minor histocompatibility (H) antigens lagged behind that of their MHC counterparts, largely because minor H antigens are recognised by T cells and not by antibodies. In the
Simpson, E, Roopenian, D C
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Minor Histocompatibility Antigens in GVL
2000In syngeneic bone marrow transplantation (BMT) and in recipients of autologous BMT, relapse rates are high. No MHC or minor histocompatibility antigen (mHag) disparities exist and thus no alloreactivities can be induced. This is clearly different in allogeneic BMT, where the relapse rates are significantly lower and a relationship is seen between the ...
Mutis, Tuna, Goulmy, Els
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Tolerance to minor histocompatibility antigens
Immunology Letters, 1988A neonatal tolerance model employing fully allogeneic lymphoid cells as tolerogen was used in an investigation of tolerance to self and donor minor histocompatibility antigens (miHA). Tolerance was assessed by skin grafting and subsequently by the generation of cytotoxic T lymphocytes. Two strain combinations were investigated. In the first, BALB/c-B10,
L S, Rayfield, L, Brent, K, Samuel
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Minor histocompatibility antigens
Immunology Letters, 1991Immune responses against foreign tissue or organs can be directed against alloantigenic differences between donor and host encoded by genes of the major histocompatibility complex (MHC; HLA in man and H-2 in mouse). However, when MHC antigens are matched, as in HLA-identical siblings, or between different mouse strains sharing the same H-2 haplotype ...
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The immunogenomics of minor histocompatibility antigens
Immunological Reviews, 2002Summary: Minor histocompatibility (H) antigens are a diverse assemblage of major histocompatibility complex (MHC)‐bound peptides with the unifying property of acting as alloantigens that induce allogeneic tissue rejection. They are a consequence of any form of accumulated genetic variation that translates to differential MHC‐presented peptide epitopes,
Roopenian, D, Choi, E Y, Brown, A
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The genetic origin of minor histocompatibility antigens
Immunogenetics, 1993The purpose of this study was to elucidate the genetic origin of minor histocompatibility (H) antigens. Toward this end common inbred mouse strains, distinct subspecies, and species of the subgenus Mus were examined for expression of various minor H antigens.
Roopenian, D C +4 more
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Minor Histocompatibility Antigens and Marrow Transplantation
New England Journal of Medicine, 1996Acute graft-versus-host disease (GVHD) and graft rejection are the principal obstacles to successful allogeneic bone marrow transplantation.
N A, Kernan, B, Dupont
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Major vs minor histocompatibility antigens
Blood, 2017In this issue of Blood, Martin et al found that the number of minor histocompatibility antigen mismatches doubles in unrelated vs sibling HLA-matched transplants, but has less impact on graft-versus-host disease (GVHD) than mismatching at HLA-DP ...
Denis Claude Roy, Claude Perreault
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