Results 101 to 110 of about 1,087,727 (251)
Rheumatology &Autoimmunity, EarlyView.A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa +3 more
wiley +1 more source
Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]
, 1991 Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Reddehase, Matthias J. +9 more
core +1 more source
T-Cell Stimulation by Melanoma RNA-Pulsed Dendritic Cells [PDF]
, 2004 In situations where well-established approaches such as surgery, radiation therapy and chemotherapy fail to help cancer patients, immunotherapy has the potential to be an effective alternative.
Javorovic, Miran
core +1 more source
Genomic Assessment of Reintroduced African Wild Dogs Informs Conservation Translocations
Animal Conservation, EarlyView.Few reintroduction and translocation programs incorporate genomic assessments into management planning, despite ongoing debate over how founder individuals should be selected. Here, we assess the genomic composition of reintroduced African wild dog (Lycaon pictus) populations in private reserves in South Africa, comparing them with a free‐roaming ...
Michou Weimar +4 more
wiley +1 more source
The Expression of Sex-Specific and Autosomal Minor Histocompatibility Antigens by the Placenta
, 2013 Full text is available to authenticated members of The University of Auckland only.Introduction: Minor histocompatibility antigens were identified as causing organ transplant rejection in HLAmatched donor/recipient pairs (1).
Gamage, Teena
core
Immunological basis of differences in disease resistance in the chicken [PDF]
, 2002 Genetic resistance to diseases is a multigenic trait governed mainly by the immune system and its interactions with many physiologic and environmental factors.
Rebel, J.M.J. +5 more
core +1 more source
Pregnancy: an immune challenge
Semina: Ciências Biológicas e da Saúde, 2014 Several studies demonstrate the importance of immunological aspects of pregnancy. During pregnancy, the embryo is implanted in the womb, where it will develop until the end of pregnancy.
Maria Angelica Ehara Watanabe +6 more
doaj +1 more source
Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells
Allergy, EarlyView.We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller +16 more
wiley +1 more source
Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]
, 1992 The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef +7 more
core +1 more source
PLoS ONE, 2014 Allogeneic stem cell transplantation (alloSCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to treat malignant diseases.
Cornelis A M van Bergen +10 more
doaj +1 more source