Results 81 to 90 of about 56,759 (294)

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Host immune response to cytomegalovirus [PDF]

, 1987
To confirm that immediate-early (IE) genes of murine cytomegalovirus (MCMV) give rise to antigens recognized by specific cytolytic T lymphocytes (CTL), a 10.8-kilobase fragment of MCMV DNA which is abundantly transcribed at IE times was transfected into ...
Keil, Günther M., Koszinowski, Ulrich H., Reddehase, Matthias J., Schickedanz, Jörg   +3 more
core  

Regulatory immune cells in transplantation [PDF]

, 2012
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control the innate immune response triggered by the injured ...
Bushell, Andrew, Hester, Joanna, Wood, Kathryn J   +2 more
core   +1 more source

Spontaneous regression of equine sarcoids is an exceptional event

Equine Veterinary Journal, EarlyView.
Abstract Sarcoids are benign, yet locally aggressive skin tumours that commonly affect horses and other equid species. The lesions are induced by bovine papillomavirus types 1, 2, and probably 13 in conjunction with other factors including trauma and a genetic predisposition.
Sabine Brandt
wiley   +1 more source

Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb [PDF]

, 1999
Background. We previously reported the association among donor leukocyte chimerism, apoptosis of presumedly IL-2-deficient graft-infiltrating host cells, and the spontaneous donor-specific tolerance induced by liver but not heart allografts in mice ...
Angus W. Thomson, Aust, Bishop, Bishop, Buhlmann, Cohn, Cuiping Zhong, Dai, Demetris, Durie, Effros, Ehl, Fu, Hancock, Inaba, Janeway, Jenkins, John J. Fung, Kneitz, Konieczny, Larsen, Larsen, Lenschow, Lina Lu, Lu, Lu, Lu, Lu, Lu, Markees, Matzinger, Meyer, Morecki, Murase, Murase, Murase, Niimi, Ohashi, Ohashi, Parker, Picker, Qian, Qian, Rafaeli, Rastellini, Sayegh, Schwartz, Shiguang Qian, Starzl, Starzl, Starzl, Starzl, Sun, Taniguchi, Thomas E. Starzl, Thomson, Thomson, Van Parijs, Wei Li, Wekerle, Willerford, Zinkernagel, Zinkernagel, Zinkernagel   +63 more
core   +1 more source

Recent Advances in Thalassemia Research: A Comprehensive Assessment From Diagnostic Technologies to Clinical Treatment

Journal of Clinical Laboratory Analysis, EarlyView.
Thalassemia, a common hereditary blood disorder causing impaired globin synthesis and related complications, has seen remarkable progress in recent years due to advancements in genomics and molecular biology. Researchers have identified various gene variants related to thalassemia and improved clinical diagnostic methods, including new genetic testing ...
Chaoqiong Zhou, Ting Chen, Ying Huang, Huali Wang, Dahai He, Feng Wu, Yan Zhang, Lirui Kong   +7 more
wiley   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, EarlyView.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells [PDF]

, 2018
Dendritic cells (DCs) produce major histocompatibility complex II (MHCII) in large amounts to function as professional antigen presenting cells. Paradoxically, DCs also ubiquitinate and degrade MHCII in a constitutive manner.
Anderson, Anderson, Baravalle, Bartee, Berditchevski, Björkholm, Charrin, Charrin, Chen, Chyi-Song Hsieh, Corcoran, De Gassart, Giudicelli, Golshayan, Hanada, Haribhai, Heather Pua, Hiltbold, Hoffmann, Hsieh, Hsieh, Jaehak Oh, Jeoung-Sook Shin, Justin S.A. Perry, Kato, Klein, Kondoh, Kropshofer, Kurts, Lehner, Matsuki, Metz, Mottet, Nicole Irgens-Möller, Odintsova, Oh, Oh, Ohmura-Hoshino, Perry, Powrie, Roy, Sachl, Sala-Valdés, Satoshi Ishido, Sharom, Shin, Simons, Stritesky, Unternaehrer, van Niel, Veerapathran, Walseng, Yamaji, Yamazaki, Zimmerman   +54 more
core   +2 more sources

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source