Results 81 to 90 of about 30,003 (256)

Interferon y Stimulation Modulates the Proteolytic Activity and Cleavage Site Preference of 20S Mouse Proteasomes [PDF]

, 1994
The proteasome is a 700-kD multisubunit enzyme complex with several proteolytically active sites. The enzyme complex is involved in both ubiquitin-dependent and -independent protein degradation and may contribute to the processing of antigens presented ...
Multhaupt, Gerd, Koszinowski, Ulrich H., Kloetzel, Peter-M., Boes, Bettina, Ruppert, Thomas, Hengel, Hartmut   +5 more
core  

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

Gene expression signatures from single‐cell transcriptomics predict Sjögren's syndrome

iMetaOmics, EarlyView.
A machine learning‐based 12‐gene signature (SjS.Sig) was developed from scRNA‐seq data of PBMCs from Sjögren's syndrome patients. The model was validated using bulk RNA‐seq datasets and further confirmed through flow cytometry and qPCR analysis in an independent clinical cohort, demonstrating robust diagnostic potential.
Shumin Cheng, Ling Yan, Yilin Wu, Yan Li, Ziheng Ye, Zhen Zhang, Yi Zhang, Jingyun Ma, Yuhong Liang, Zhaofan Luo, Huacheng Wang, Meili Gao, Chao Qin, Ke Zhu, Yun Leng, Kamran Ullah, Jun Liang, Haiyan Yan, Guan Yang, Yingqian Mo, Bihui Huang   +20 more
wiley   +1 more source

C19orf48 encodes a minor histocompatibility antigen recognized by CD8+ cytotoxic T cells from renal cell carcinoma patients [PDF]

, 2008
PURPOSE: Tumor regression has been observed in some patients with metastatic renal cell carcinoma (RCC) after nonmyeloablative allogeneic hematopoietic cell transplantation (HCT).
Riddell, Stanely R., Sharon M. Lu, Edus H. Warren, Warren, Edus H, Mito, Jeffrey K., Sandmaier, Brenda M., John A. Thompson, Nobuharu Fujii, Tykodi, Scott S, Scott S. Tykodi, Jeffrey Chou, Voong, Lilien N, Nathalie Vigneron, Miranda, Maureen X, Voong, Lilien N., Riddell, Stanley R, Fujii, Nobuharu, Chou, Jeffrey, Van den Eynde, Benoît, Sandmaier, Brenda M, Vigneron, Nathalie, Cresswell, Peter, Thompson, John A, Brenda M. Sandmaier, Peter Cresswell, Jeffrey K. Mito, Stanley R. Riddell, Lu, Sharon M., Thompson, John A., Miranda, Maureen X., Mito, Jeffrey K, Maureen X. Miranda, Lu, Sharon M, Lilien N. Voong, Benoît Van den Eynde, Warren, Edus H., Tykodi, Scott S.   +36 more
core   +1 more source

Paradoxical Alopecia Areata Induced by IL‐17 and IL‐23 Inhibitors: A Systematic Review

JEADV Clinical Practice, EarlyView.
This systematic review identifies consistent clinical patterns of alopecia areata associated with IL‐17 and IL‐23 inhibitors, most frequently involving secukinumab and ustekinumab. Disease severity varied widely, and management often required biologic discontinuation or therapeutic switching.
Isabella Kamholtz, Simonetta I. Gaumond, Joaquin J. Jimenez   +2 more
wiley   +1 more source

CCR Translation on this Article from C19orf48 Encodes a Minor Histocompatibility Antigen Recognized by CD8⁺ Cytotoxic T Cells from Renal Cell Carcinoma Patients

, 2008
CCR Translation on this Article from C19orf48 Encodes a Minor Histocompatibility Antigen Recognized by CD8+ Cytotoxic T Cells from Renal Cell Carcinoma ...
Jeffrey Chou (180862), John A. Thompson (266488), Nobuharu Fujii (219190), Maureen X. Miranda (14973678), Lilien N. Voong (14973681), Edus H. Warren (12486664), Peter Cresswell (289158), Stanley R. Riddell (14896908), Brenda M. Sandmaier (2100877), Nathalie Vigneron (13552195), Sharon M. Lu (14973672), Jeffrey K. Mito (14973675), Benoît Van den Eynde (2177016), Scott S. Tykodi (13789936)   +13 more
core   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Development of a sample bank and clinical database for the retrospective analysis of unrelated bone marrow transplants: a pilot study of 138 transplants using RSCA for high resolution HLA matching.

, 2005
The Anthony Nolan Register provides donors for allogeneic stem cell transplantation for haematological disorders. A clinical database and sample bank were established for the ongoing analysis of transplants from Register donors.
Pay, A.L.P.
core  

Supplementary Figures S1-S2 from C19orf48 Encodes a Minor Histocompatibility Antigen Recognized by CD8⁺ Cytotoxic T Cells from Renal Cell Carcinoma Patients

, 2008
Supplementary Figures S1-S2 from C19orf48 Encodes a Minor Histocompatibility Antigen Recognized by CD8+ Cytotoxic T Cells from Renal Cell Carcinoma ...
Jeffrey Chou (180862), John A. Thompson (266488), Nobuharu Fujii (219190), Maureen X. Miranda (14973678), Lilien N. Voong (14973681), Edus H. Warren (12486664), Peter Cresswell (289158), Stanley R. Riddell (14896908), Brenda M. Sandmaier (2100877), Nathalie Vigneron (13552195), Sharon M. Lu (14973672), Jeffrey K. Mito (14973675), Benoît Van den Eynde (2177016), Scott S. Tykodi (13789936)   +13 more
core   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source