Results 71 to 80 of about 30,003 (256)

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

High-throughput minor histocompatibility antigen prediction [PDF]

Bioinformatics, 2009
Abstract Motivation: Minor histocompatibility antigens (mHags) are a diverse collection of MHC-bound peptides that have immunological implications in the context of allogeneic transplantation because of their differential presence in donor and host, and thus play a critical role in the induction of the detrimental graft-versus-host ...
David S. DeLuca, Britta Eiz-Vesper, Nektarios Ladas, Barbara Anna-Maria Khattab, Rainer Blasczyk   +4 more
openaire   +2 more sources

Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans

, 2003
One of the factors that increases the risk of graft-versus-host disease following allogeneic stem cell transplantation is the use of multiparous females as donors.
James, E., Francesco Dazzi, Edward James, Dazzi, F., Chai, J.G., Hamlata Dewchand, Chai, J. G., Dewchand, H., Simpson, E., Eugenio Macchiarulo, Macchiarulo, E., Dazzi, F.; id_orcid, Elizabeth Simpson, Jian-Guo Chai   +13 more
core   +1 more source

A glow of HLA typing in organ transplantation

Clinical and Translational Medicine, 2013
The transplant of organs and tissues is one of the greatest curative achievements of this century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the main goal of the immune ...
Batool Mutar Mahdi
doaj   +1 more source

Mimic, target, and adapt: Cell membrane‐coated nanoplatforms for precision and immune‐guided cancer treatment

BMEMat, EarlyView.
This Perspective explores the emerging landscape of cell membrane‐coated nanoparticles (CM‐NPs) as intelligent, immune‐compatible platforms for cancer therapy. Highlighting design strategies, translational challenges, and competitive positioning, it outlines how integrating biomimetic targeting with advanced analytical and manufacturing tools could ...
A. K. M. M. Alam, Xiaojun Cai, Malik Ihsan Ullah Khan, Robert Musiol, Quazi T. H. Shubhra   +4 more
wiley   +1 more source

Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen-specific cytotoxic T lymphocytes

, 2004
Cytotoxic T lymphocytes (CTLs) specific for hematopoietic-restricted minor histocompatibility antigens (mhags) are important reagents for adoptive immunotherapy of relapsed leukemia after allogeneic stem call transplantation.
Curtsinger, Julie, Blokland, Els, Goulmy, Els, Van Halteren, Astrid G S, Falkenburg, J. H Frederik, Mutis, Tuna, Mescher, Matthew F., Oosten, Liesbeth E M   +7 more
core   +1 more source

T cell responses against minor histocompatibility antigen HA‐1

, 2021
Allogeneic immune responses underlie the graft-versus-leukaemia effect of stem cell transplantation, but disease relapse occurs in many patients. Minor histocompatibility antigen (mHAg) peptides mediate alloreactive T cell responses and induce graft ...
Donna Walsh, Eldershaw, S.A., Inman, C.F., Wayne Croft, Sandeep Nagra, Begum, J., Ferguson, P., Powell, R., Richard Powell, Shamyla Saddique, Nagra, S., Ram Malladi, Nicol, S., Nunnick, J., Christine Stephens, Samantha Nicol, Jusnara Begum, Hayden Pearce, Mirjana Sirovica, Sirovica, M., Taylor, G., Charlotte F. Inman, Piper, K.P., Saddique, S., Graham Taylor, Paul Ferguson, Pearce, H.; id_orcid, Abbotts, B., Walsh, D., Ben Abbotts, Paul Moss, Malladi, R., Suzy A. Eldershaw, Jane Nunnick, Stephens, C., Moss, P.; id_orcid, Karen P. Piper, Croft, W.; id_orcid   +37 more
core   +1 more source

Does minor histocompatibility antigen HA-1 disparity affect the occurrence of graft-versus-host disease in tunisian recipients of hematopoietic stem cells?

Clinics, 2010
INTRODUCTION: Minor histocompatibility antigen HA-1 (MiHAg-HA-1) disparity between a patient and his or her human leukocyte antigen (HLA) genoidentical donor has been widely associated with an increased risk of graft-versus-host disease following ...
Mohamed Hichem Sellami, Lamia Torjemane, Alejandro Espadas de Arias, Houda Kaabi, Saloua Ladeb, Francesca Poli, Tarek Ben Othmane, Slama Hmida   +7 more
doaj   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Natural Regulation of Immunity to Minor Histocompatibility Antigens [PDF]

The Journal of Immunology, 2007
Abstract MHC-matched hemopoietic stem cell transplantation is commonly used for the treatment of some forms of leukemia. Conditioning regimens before transplant act to reduce the burden of leukemic cells and the graft-vs-leukemia (GvL) effect can eliminate residual disease.
Robertson, Nathan J, Chai, Jian-Guo, Millrain, Maggie, Scott, Diane, Hashim, Fazila, Manktelow, Emily, Lemonnier, François, Simpson, Elizabeth, Dyson, Julian   +8 more
openaire   +3 more sources