Results 91 to 100 of about 56,759 (294)

Targeting of T Lymphocytes to Melanoma Cells Through Chimeric Anti-GD3 Immunoglobulin T-Cell Receptors

Neoplasia: An International Journal for Oncology Research, 2000
Immunoglobulin T-cell receptors (IgTCRs) combine the specificity of antibodies with the potency of cellular killing by grafting antibody recognition domains onto TCR signaling chains.
C.O. Yun, K.F. Nolan, E.J. Beecham, R.A. Reisfeld, P. Junghans   +4 more
doaj   +1 more source

EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice

JCI Insight, 2022
Insight into processes that determine CD8+ T cell memory formation has been obtained from infection models. These models are biased toward an inflammatory milieu and often use high-avidity CD8+ T cells in adoptive-transfer procedures.
Armin Rehm, Anthea Wirges, Dana Hoser, Cornelius Fischer, Stefanie Herda, Kerstin Gerlach, Sascha Sauer, Gerald Willimsky, Uta E. Höpken   +8 more
doaj   +1 more source

The evolving role of regulatory T cells in Sjögren's disease pathogenesis and the promise of Treg‐based therapies: A comprehensive review

Rheumatology &Autoimmunity, EarlyView.
Graphical Abstract The evolving role of regulatory T cells in primary Sjögren's disease pathogenesis and the promise of Treg‐based therapies. Abstract Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by exocrine gland dysfunction and diverse systemic manifestations.
Gagan Urs, Bharath Raj Srinivasan, Himabindu Jayaprakash Narayan, Mirunalini Gobinath, Lekitha Manjunath, Mahabaleshwar Mamadapur   +5 more
wiley   +1 more source

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Chen, Xiao, Guenther, Wolfgang, Kolb, Hans-Jochem, Ledderose, Georg, Roskrow, Marie, Schleuning, Michael, Schmid, Christoph, Weber, Martin, Woiciechowski, Anja   +8 more
core   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?

PLoS ONE, 2014
Allogeneic stem cell transplantation (alloSCT) followed by donor lymphocyte infusion (DLI) can be applied as immunotherapeutic intervention to treat malignant diseases.
Cornelis A M van Bergen, Elisabeth M E Verdegaal, M Wilhelmina Honders, Conny Hoogstraten, A Q M Jeanne Steijn-van Tol, Linda de Quartel, Joan de Jong, Maaike Meyering, J H Frederik Falkenburg, Marieke Griffioen, Susanne Osanto   +10 more
doaj   +1 more source

Differential gene analysis during the development of obliterative bronchiolitis in a murine orthotopic lung transplantation model: A comprehensive transcriptome-based analysis.

PLoS ONE, 2020
BACKGROUND:Obliterative bronchiolitis (OB) is a known issue during minor histocompatibility antigen (mHA) disparity during lung transplantation. This study evaluated gene expression in a murine orthotropic lung transplantation model using microarray ...
Atsushi Hata, Hidemi Suzuki, Takahiro Nakajima, Taiki Fujiwara, Yuki Shiina, Taisuke Kaiho, Takahide Toyoda, Terunaga Inage, Takamasa Ito, Yuichi Sakairi, Hajime Tamura, Hironobu Wada, Yoshito Yamada, Masako Chiyo, Keisuke Matsusaka, Masaki Fukuyo, Ken-Ichi Shinohara, Sakae Itoga, Shinichiro Motohashi, Kazuyuki Matsushita, Atsushi Kaneda, Ichiro Yoshino   +21 more
doaj   +1 more source

Minor histocompatibility antigens [PDF]

Blood, 1990
C, Perreault, F, Décary, S, Brochu, M, Gyger, R, Bélanger, D, Roy   +5 more
openaire   +3 more sources

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Pregnancy: an immune challenge

Semina: Ciências Biológicas e da Saúde, 2014
Several studies demonstrate the importance of immunological aspects of pregnancy. During pregnancy, the embryo is implanted in the womb, where it will develop until the end of pregnancy.
Maria Angelica Ehara Watanabe, Ellen Cristine Duarte-Garcia, Giovana Gomes de Carvalho, Natália Kimie Matsubara, Ana Camila Vaitkevicius Ferreira, Nágela Ghabdan Zanluqui, Gabriela Gonçalves de Oliveira   +6 more
doaj   +1 more source