Results 51 to 60 of about 56,759 (294)

Minor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade

Journal of Immunology Research, 2016
Mixed chimerism and tolerance can be successfully induced in rodents through allogeneic bone marrow transplantation (BMT) with costimulation blockade (CB), but varying success rates have been reported with distinct models and protocols.
Sinda Bigenzahn, Ines Pree, Christoph Klaus, Nina Pilat, Benedikt Mahr, Elisabeth Schwaiger, Patrick Nierlich, Friedrich Wrba, Thomas Wekerle   +8 more
doaj   +1 more source

Tolerogenic effect of noninherited maternal antigens in hematopoietic stem cell transplantation

Frontiers in Immunology, 2012
Major histocompatibility complex antigens that provoke severe transplant reactions are referred to as the human leukocyte antigen (HLA) in human and as the H-2 in mice.
Masahiro eHirayama, Eiichi eAzuma, Yoshihiro eKomada   +2 more
doaj   +1 more source

Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model

Inflammation and Regeneration, 2022
Background Off-the-shelf major histocompatibility complex (MHC)-matched iPS cells (iPSC) can potentially initiate host immune responses because of the existence of numerous minor antigens.
Tomoki Kamatani, Ryo Otsuka, Tomoki Murata, Haruka Wada, Takeshi Takahashi, Akihiro Mori, Soichiro Murata, Hideki Taniguchi, Ken-ichiro Seino   +8 more
doaj   +1 more source

Carbohydrate moieties of major histocompatibility complex class I alloantigens are not required for their recognition by T lymphocytes. [PDF]

, 1985
The ability to generate specific cytotoxic responses using purified major histocompatibility complex (MHC) antigen in liposomes has made it possible to directly assess the importance of class I carbohydrate moieties in T cell recognition of alloantigen ...
Goldstein, SA, Mescher, MF
core  

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Toward a network model of MHC class II-restricted antigen processing

Frontiers in Immunology, 2013
The standard model of Major Histocompatibility Complex class II (MHCII)-restricted antigen processing depicts a straightforward, linear pathway: Internalized antigens are converted into peptides that load in a chaperone dependent manner onto nascent ...
Laurence C Eisenlohr, Michael A Miller, Asha Purnima Veerappan Ganesan   +2 more
doaj   +1 more source

TCR-Like CAR-T Cells Targeting MHC-Bound Minor Histocompatibility Antigens

Frontiers in Immunology, 2020
Minor histocompatibility antigens (mHAgs) in allogeneic hematopoietic stem cell transplantation are highly immunogenic as they are foreign antigens and cause polymorphism between donors and recipients. Adoptive cell therapy with mHAg-specific T cells may
Yoshiki Akatsuka
doaj   +1 more source

Role of early viral surface antigens in cellular immune response to vaccinia virus [PDF]

, 1976
Infection of mice with the vaccinia virus strain WR, Elstree or DIs, a conditional lethal mutant of vaccinia virus, resulted in the generation of vaccinia virus-specific sensitized cytolytic T lymphocytes (CTL).
Ertl, H., Koszinowski, Ulrich H.
core   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Antigen-specific priming is dispensable in depletion of apoptosis-sensitive T cells for GvHD prophylaxis

Frontiers in Immunology, 2014
Prophylactic approaches to graft versus host disease (GvHD) have employed both phenotypic reduction of T cells and selective elimination of host-primed donor T cells in vitro and in vivo.
Shai eYarkoni, Jerry eStein, Isaac eYaniv, Nadir eAskenasy   +3 more
doaj   +1 more source