Results 41 to 50 of about 30,003 (256)

Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance. [PDF]

Transpl Immunol, 2013
Alloreactive T-cell responses directed against minor histocompatibility (H) antigens, which arise from diverse genetic disparities between donor and recipient outside the MHC, are an important cause of rejection of MHC-matched grafts.
Hess SM, Young EF, Miller KR, Vincent BG, Buntzman AS, Collins EJ, Frelinger JA, Hess PR.   +7 more
europepmc   +2 more sources

Expanding the immunotherapeutic potential of minor histocompatibility antigens [PDF]

Journal of Clinical Investigation, 2005
Minor histocompatibility antigens (mHAgs) selectively expressed by cells or cell subsets of the hematopoietic system are targets of the T cell-mediated graft-versus-leukemia response that develops following allogeneic hematopoietic stem cell transplantation (HSCT) for the treatment of hematological malignancies.
Eric, Spierings, Els, Goulmy
openaire   +2 more sources

Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]

, 2003
Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Kolb, Hans-Jochem, Roskrow, Marie, Guenther, Wolfgang, Schmid, Christoph, Ledderose, Georg, Weber, Martin, Chen, Xiao, Schleuning, Michael, Woiciechowski, Anja   +8 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein [PDF]

, 1991
Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is documented that not only the sequence of the presented peptide but also the residues by which it is ...
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schlicht, Hans-Jürgen, Ruppert, Thomas   +4 more
core   +1 more source

Immunologic ignorance of vascular endothelial cells expressing minor histocompatibility antigen. [PDF]

Blood, 2008
Endothelial cells (ECs) presenting minor histocompatibility antigen (mhAg) are major target cells for alloreactive effector CD8(+) T cells during chronic transplant rejection and graft-versus-host disease (GVHD).
Bolinger B, Krebs P, Tian Y, Engeler D, Scandella E, Miller S, Palmer DC, Restifo NP, Clavien PA, Ludewig B.   +9 more
europepmc   +2 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Role of Minor Histocompatibility Antigens in Renal Transplantation [PDF]

American Journal of Transplantation, 2008
In hematopoietic stem cell transplantation (HSCT), disparities between recipients and donors for minor histocompatibility antigens (mHags) have been shown to be related to graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects. We investigated the effect of mHag mismatches on kidney allograft survival. Out of 33 785 kidney transplants
A, Heinold, G, Opelz, S, Scherer, A, Ruhenstroth, G, Laux, B, Doehler, T H, Tran   +6 more
openaire   +2 more sources

HLA class I-minor histocompatibility antigen tetramers select cytotoxic T cells with high avidity to the natural ligand.

, 2000
INTRODUCTION: Cytotoxic T cells specific for the hematopoietic system-restricted minor histocompatibility antigens HA-1 and HA-2 are potential tools for the treatment of relapsed leukemia after minor histocompatibility antigen mismatched bone marrow ...
Moss, P., JH Frederik Falkenburg, Ellen Schrama, Kamp, J., Mutis, T., Moss, P, Gillespie, G., Schrama, E, Els Goulmy, Falkenburg, J.H.F., Esendam, B, Falkenburg, JF, Schrama, Ellen, Bennie Esendam, Esendam, Bennie, Kamp, Janine, Gillespie, Geraldine, Goulmy, Els, Tuna Mutis, Geraldine Gillespie, Mutis, T, Moss, Paul, Kamp, J, Goulmy, E.A.J.M., Janine Kamp, Gillespie, G, Esendam, B., Mutis, Tuna, Paul Moss, Falkenburg, J. H.Frederik, Goulmy, E, Schrama, E.   +31 more
core   +1 more source

Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens

Blood Advances, 2018
: T-cell responses to minor histocompatibility antigens (mHAs) mediate both antitumor immunity (graft-versus-leukemia [GVL]) and graft-versus-host disease (GVHD) in allogeneic stem cell transplant.
Jefferson L. Lansford, Udara Dharmasiri, Shengjie Chai, Sally A. Hunsucker, Dante S. Bortone, James E. Keating, Ian M. Schlup, Gary L. Glish, Edward J. Collins, Gheath Alatrash, Jeffrey J. Molldrem, Paul M. Armistead, Benjamin G. Vincent   +12 more
doaj   +1 more source