Results 31 to 40 of about 56,759 (294)

A Review of Cyclophosphamide-Induced Transplantation Tolerance in Mice and Its Relationship With the HLA-Haploidentical Bone Marrow Transplantation/Post-Transplantation Cyclophosphamide Platform

Frontiers in Immunology, 2021
The bone marrow transplantation (BMT) between haplo-identical combinations (haploBMT) could cause unacceptable bone marrow graft rejection and graft-versus-host disease (GVHD).
Hisanori Mayumi
doaj   +1 more source

T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

Nature Communications, 2020
In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can ...
Meng Zhou, Faruk Sacirbegovic, Kai Zhao, Sarah Rosenberger, Warren D. Shlomchik   +4 more
doaj   +1 more source

Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]

, 1989
Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Doerner, C., Kuon, W., Pohla, Heike, Tabaczewski, P., Weiss, Elisabeth H.   +4 more
core   +1 more source

High-throughput minor histocompatibility antigen prediction [PDF]

Bioinformatics, 2009
Abstract Motivation: Minor histocompatibility antigens (mHags) are a diverse collection of MHC-bound peptides that have immunological implications in the context of allogeneic transplantation because of their differential presence in donor and host, and thus play a critical role in the induction of the detrimental graft-versus-host ...
David S, DeLuca, Britta, Eiz-Vesper, Nektarios, Ladas, Barbara Anna-Maria, Khattab, Rainer, Blasczyk   +4 more
openaire   +2 more sources

Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease

Frontiers in Immunology, 2022
Hematopoietic allogeneic stem cell transplantation (allo-SCT) is a curative option for patients with hematological malignancies. However, due to disparities in major and minor histocompatibility antigens between donor and recipient, severe inflammatory ...
Matteo Doglio, Rachel E. Crossland, Ana C. Alho, Ana C. Alho, Olaf Penack, Anne M. Dickinson, Anne M. Dickinson, Georg Stary, Georg Stary, Georg Stary, João F. Lacerda, João F. Lacerda, Günther Eissner, Marit Inngjerdingen   +13 more
doaj   +1 more source

Targeting the Retinoid X Receptor Pathway Prevents and Ameliorates Murine Chronic Graft-Versus-Host Disease

Frontiers in Immunology, 2022
Most allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients receive peripheral blood stem cell grafts resulting in a 30%–70% incidence of chronic graft-versus-host disease (cGVHD), a major cause of mortality and morbidity in long-term ...
Govindarajan Thangavelu, Michael C. Zaiken, Fathima A. Mohamed, Ryan Flynn, Jing Du, Stephanie Y. Rhee, Megan J. Riddle, Ethan G. Aguilar, Angela Panoskaltsis-Mortari, Martin E. Sanders, Bruce R. Blazar   +10 more
doaj   +1 more source

Molecular modeling of an antigenic complex between a viral peptide and a class I major histocompatibility glycoprotein [PDF]

, 1992
Computer simulation of the conformations of short antigenic peptides (&lo residues) either free or bound to their receptor, the major histocompatibility complex (MHC)- encoded glycoprotein H-2 Ld, was employed to explain experimentally determined ...
Allen, Babbit, Bjorkman, Buus, Chen, Cramer, Del Val, DeLisi, Falk, Fauchère, Garrett, Jorgensen, Kidera, Kourilsky, Krug, Lambert, Lambert, Lambert, Margalit, Maryanski, Owen, Reddehase, Reddehase, Reddehase, Rötzschke, Saper, Schwartz, Serrano, Sette, Tirado-Rives, Townsend, Townsend, Townsend, Unanue, Van Bleek, Weiner, Wendoloski, Wold, Zinkernagel   +38 more
core   +1 more source

Involvement of Male-Specific Minor Histocompatibility Antigen H-Y in Epidermal Equivalent Allograft Rejection

Cell Transplantation, 1998
This study describes the involvement of male-specific minor histocompatibility antigen H-Y in vitro cultured epidermal equivalent (EE) rejection. Male and female Balb/c or C3H/HeN keratinocytes were isolated and cultured separately.
Marie-Josée Beaulieu, Hui Li, Julie Bergeron, Geneviève Ross, François A. Auger, Mahmoud Rouabhia   +5 more
doaj   +1 more source

Genetic engineering of virus-specific T cells with T-cell receptors recognizing minor histocompatibility antigens for clinical application

Haematologica, 2008
Background Donor lymphocyte infusion is an effective form of adoptive immunotherapy for hematologic malignancies after allogeneic stem cell transplantation.
Marieke Griffioen, H.M. Esther van Egmond, Helen Barnby-Porritt, Menno A.W.G. van der Hoorn, Renate S. Hagedoorn, Michel G.D. Kester, Nikolai Schwabe, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +9 more
doaj   +1 more source

Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]

, 2018
CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar, Edwards, Lindy, Jurtz, Vanessa, Karosiene, Edita, Nielsen, Morten, Paul, Sinu, Peters, Bjoern, Sette, Alessandro   +7 more
core   +6 more sources