Results 11 to 20 of about 56,759 (294)

DNA barcoded peptide-MHC multimers to measure and monitor minor histocompatibility antigen-specific T cells after allogeneic stem cell transplantation [PDF]

Journal for ImmunoTherapy of Cancer
Allogeneic stem cell transplantation (alloSCT) provides a curative treatment option for hematological malignancies. After HLA-matched alloSCT, donor-derived T cells recognize minor histocompatibility antigens (MiHAs), which are polymorphic peptides ...
Sine R Hadrup, Marieke Griffioen, J H Frederik Falkenburg, Mirjam H M Heemskerk, Marian van de Meent, Michel G D Kester, Kyra J Fuchs, Marcus Göransson, Natasja W Ettienne, Rob C M de Jong, Eva A S Koster, Constantijn J M Halkes, Ferenc Scheeren, Peter van Balen   +13 more
doaj   +2 more sources

Prolonged Skin Graft Survival and Histocompatibility in Highly Inbred Miniature Swine [PDF]

Transplantation Direct
Background. Pigs are potential organ donors for humans. Some proposed xenotransplant tolerance regimens require genetically identical cells from different animals (eg, juvenile bone marrow and mature organs or tissues).
Elin Manell, DVM, PhD, Harko Mulder, MSc, J. Scott Arn, BS, Esad Gunes, MD, Ishit Chauhan, MD, Satyajit Patwardhan, MD, Julie Hong, MD, Ibrahim Batal, MD, David H. Sachs, MD, Joshua Weiner, MD   +9 more
doaj   +2 more sources

A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications. [PDF]

PLoS ONE, 2006
BACKGROUND: Minor Histocompatibility (H) antigen mismatches significantly influence the outcome of HLA-matched allogeneic stem cell transplantation. The molecular identification of human H antigens is increasing rapidly. In parallel, clinical application
Eric Spierings, Jos Drabbels, Matthijs Hendriks, Jos Pool, Marijke Spruyt-Gerritse, Frans Claas, Els Goulmy   +6 more
doaj   +2 more sources

LB-ARHGDIB-1R as a novel minor histocompatibility antigen for therapeutic application [PDF]

Haematologica, 2015
Margot J. Pont, Willemijn Hobo, Maria W. Honders, Simone A.P. van Luxemburg-Heijs, Michel G.D. Kester, Annemarie M. van Oeveren-Rietdijk, Nicolaas Schaap, Hetty C. de Boer, Cornelis A.M. van Bergen, Harry Dolstra, J.H. Frederik Falkenburg, Marieke Griffioen   +11 more
doaj   +2 more sources

A polymorphism in the splice donor site of ZNF419 results in the novel renal cell carcinoma-associated minor histocompatibility antigen ZAPHIR. [PDF]

PLoS ONE, 2011
Nonmyeloablative allogeneic stem cell transplantation (SCT) can induce remission in patients with renal cell carcinoma (RCC), but this graft-versus-tumor (GVT) effect is often accompanied by graft-versus-host disease (GVHD).
Kelly Broen, Henriette Levenga, Johanna Vos, Kees van Bergen, Hanny Fredrix, Annelies Greupink-Draaisma, Michel Kester, J H Frederik Falkenburg, Pieter de Mulder, Theo de Witte, Marieke Griffioen, Harry Dolstra   +11 more
doaj   +2 more sources

In Search of Immunodominant Minor Histocompatibility Antigens [PDF]

Biology of Blood and Marrow Transplantation, 2012
survival. Larger retrospective studies should parse out relapse risk in specific cytogenetic subgroups, to offer more guidance to the practicing clinician. Our hope is that this and other retrospective studies of MRD monitoring leads to an assessment of the prognostic impact of MRD in well-defined molecular and cytogenetic subsets of AML.
Claude Perreault
openalex   +3 more sources

Human minor histocompatibility antigens

Transplant Immunology, 1993
For over five decades minor histocompatibility (mH) antigens have contmued to fascmate immimologists, mainly because of their minor but distinct role in transplantation but no less because of their as yet unknown nature In the 1970s lt became evident that mH antigens were recognized in a MHC restncted fashion, an important feature which was poorly ...
M, de Bueger, E, Goulmy
  +8 more sources

T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies

Frontiers in Immunology, 2020
Over the last decades, T-cell immunotherapy has revealed itself as a powerful, and often curative, strategy to treat blood cancers. In hematopoietic cell transplantation, most of the so-called graft-vs.-leukemia (GVL) effect hinges on the recognition of ...
Valérie Janelle, Caroline Rulleau, Simon Del Testa, Cédric Carli, Jean-Sébastien Delisle, Jean-Sébastien Delisle, Jean-Sébastien Delisle   +6 more
doaj   +1 more source

The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction

Frontiers in Immunology, 2020
For hundreds of thousands of years, the human genome has extensively evolved, resulting in genetic variations in almost every gene. Immunological reflections of these genetic variations become clearly visible after an allogeneic stem cell transplantation
Tuna Mutis, Anastasia Xagara, Anastasia Xagara, Robbert M. Spaapen, Robbert M. Spaapen   +4 more
doaj   +1 more source

Identification of minor histocompatibility antigens [PDF]

, 2003
Slavoljub Milosevic
openalex   +2 more sources