Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase [PDF]
Frontiers in Immunology, 2020 Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs.
Anita N. Kremer +13 more
doaj +7 more sources
Minor Histocompatibility Antigen-Specific T Cells [PDF]
Frontiers in Pediatrics, 2020 Minor Histocompatibility (H) antigens are major histocompatibility complex (MHC)/Human Leukocyte Antigen (HLA)-bound peptides that differ between allogeneic hematopoietic stem cell transplantation (HCT) recipients and their donors as a result of genetic ...
Corinne Summers +4 more
doaj +5 more sources
Concurrent detection of circulating minor histocompatibility antigen-specific CD8+ T cells in SCT recipients by combinatorial encoding MHC multimers. [PDF]
PLoS ONE, 2011 Allogeneic stem cell transplantation (SCT) is a potentially curative treatment for patients with hematologic malignancies. Its therapeutic effect is largely dependent on recognition of minor histocompatibility antigens (MiHA) by donor-derived CD8⁺ T ...
Kelly Broen +5 more
doaj +3 more sources
Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded by APOBEC3C [PDF]
Frontiers in Immunology, 2020 Allogeneic hematopoietic stem cell transplants can lead to dramatic reductions in human immunodeficiency virus (HIV) reservoirs. This effect is partially mediated by donor T cells recognizing lymphocyte-expressed minor histocompatibility antigens (mHAgs).
Jason T. Weinfurter +9 more
doaj +2 more sources
H60: A Unique Murine Hematopoietic Cell-Restricted Minor Histocompatibility Antigen for Graft-versus-Leukemia Effect [PDF]
Frontiers in Immunology, 2020 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for many types of hematological malignancies. Matching of donor and recipient for the major histocompatibility complex (MHC) improves the HSCT reconstitution, but ...
Eun Young Choi +7 more
doaj +2 more sources
Enhancement of Antigen Presentation by Deletion of Viral Immune Evasion Genes Prevents Lethal Cytomegalovirus Disease in Minor Histocompatibility Antigen-Mismatched Hematopoietic Cell Transplantation [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Hematoablative treatment followed by hematopoietic cell transplantation (HCT) for reconstituting the co-ablated immune system is a therapeutic option to cure aggressive forms of hematopoietic malignancies.
Emin Gezinir +5 more
doaj +2 more sources
The human minor histocompatibility antigen 1 is a RhoGAP. [PDF]
PLoS ONE, 2013 The human minor Histocompatibility Antigen HMHA-1 is a major target of immune responses after allogeneic stem cell transplantation applied for the treatment of leukemia and solid tumors.
Bart-Jan de Kreuk +9 more
doaj +2 more sources
In Silico Analysis of the Minor Histocompatibility Antigen Landscape Based on the 1000 Genomes Project [PDF]
Frontiers in Immunology, 2018 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is routinely used to treat hematopoietic malignancies. The eradication of residual tumor cells during engraftment is mediated by donor cytotoxic T lymphocytes reactive to alloantigens.
Nadia A. Bykova +2 more
doaj +2 more sources
Common minor histocompatibility antigen discovery based upon patient clinical outcomes and genomic data. [PDF]
PLoS ONE, 2011 Minor histocompatibility antigens (mHA) mediate much of the graft vs. leukemia (GvL) effect and graft vs. host disease (GvHD) in patients who undergo allogeneic stem cell transplantation (SCT).
Paul M Armistead +10 more
doaj +2 more sources
Multiplexed genotyping of human minor histocompatibility antigens
Human Immunology, 2005 Minor histocompatibility antigens (mHAg) induce major histocompatibility complex-restricted, T cell-mediated immune responses that may contribute to increased risk of graft-versus-host disease and graft-versus-leukemia effects. Unlike human leukocyte antigen genes, mHAg are encoded by genetically and functionally unrelated genes located throughout the ...
B.C. Pietz +3 more
openalex +3 more sources