Results 1 to 10 of about 205 (161)
Minor Histocompatibility Antigen-Specific T Cells
Frontiers in Pediatrics, 2020 Minor Histocompatibility (H) antigens are major histocompatibility complex (MHC)/Human Leukocyte Antigen (HLA)-bound peptides that differ between allogeneic hematopoietic stem cell transplantation (HCT) recipients and their donors as a result of genetic ...
Corinne Summers +4 more
doaj +3 more sources
The human minor histocompatibility antigen 1 is a RhoGAP. [PDF]
PLoS ONE, 2013 The human minor Histocompatibility Antigen HMHA-1 is a major target of immune responses after allogeneic stem cell transplantation applied for the treatment of leukemia and solid tumors.
Bart-Jan de Kreuk +9 more
doaj +5 more sources
T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies
Frontiers in Immunology, 2020 Over the last decades, T-cell immunotherapy has revealed itself as a powerful, and often curative, strategy to treat blood cancers. In hematopoietic cell transplantation, most of the so-called graft-vs.-leukemia (GVL) effect hinges on the recognition of ...
Valérie Janelle +6 more
doaj +1 more source
A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications. [PDF]
PLoS ONE, 2006 BACKGROUND: Minor Histocompatibility (H) antigen mismatches significantly influence the outcome of HLA-matched allogeneic stem cell transplantation. The molecular identification of human H antigens is increasing rapidly. In parallel, clinical application
Eric Spierings +6 more
doaj +1 more source
The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction
Frontiers in Immunology, 2020 For hundreds of thousands of years, the human genome has extensively evolved, resulting in genetic variations in almost every gene. Immunological reflections of these genetic variations become clearly visible after an allogeneic stem cell transplantation
Tuna Mutis +4 more
doaj +1 more source
Common minor histocompatibility antigen discovery based upon patient clinical outcomes and genomic data. [PDF]
PLoS ONE, 2011 Minor histocompatibility antigens (mHA) mediate much of the graft vs. leukemia (GvL) effect and graft vs. host disease (GvHD) in patients who undergo allogeneic stem cell transplantation (SCT).
Paul M Armistead +10 more
doaj +1 more source
Identifying a Minor Histocompatibility Antigen in Mauritian Cynomolgus Macaques Encoded by APOBEC3C
Frontiers in Immunology, 2020 Allogeneic hematopoietic stem cell transplants can lead to dramatic reductions in human immunodeficiency virus (HIV) reservoirs. This effect is partially mediated by donor T cells recognizing lymphocyte-expressed minor histocompatibility antigens (mHAgs).
Jason T. Weinfurter +9 more
doaj +1 more source
Haematologica, 2012 Background Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation.
Marieke Griffioen +7 more
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Frontiers in Immunology, 2020 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment for many types of hematological malignancies. Matching of donor and recipient for the major histocompatibility complex (MHC) improves the HSCT reconstitution, but ...
Eun Young Choi +7 more
doaj +1 more source
Identification of minor histocompatibility antigens based on the 1000 Genomes Project
Haematologica, 2014 Minor histocompatibility antigens are highly immunogeneic polymorphic peptides playing crucial roles in the clinical outcome of HLA-identical allogeneic stem cell transplantation.
Rimke Oostvogels +7 more
doaj +1 more source