Results 1 to 10 of about 30,003 (256)

A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applications. [PDF]

PLoS ONE, 2006
BACKGROUND: Minor Histocompatibility (H) antigen mismatches significantly influence the outcome of HLA-matched allogeneic stem cell transplantation. The molecular identification of human H antigens is increasing rapidly. In parallel, clinical application
Eric Spierings, Jos Drabbels, Matthijs Hendriks, Jos Pool, Marijke Spruyt-Gerritse, Frans Claas, Els Goulmy   +6 more
doaj   +3 more sources

LB-ARHGDIB-1R as a novel minor histocompatibility antigen for therapeutic application [PDF]

Haematologica, 2015
Margot J. Pont, Willemijn Hobo, Maria W. Honders, Simone A.P. van Luxemburg-Heijs, Michel G.D. Kester, Annemarie M. van Oeveren-Rietdijk, Nicolaas Schaap, Hetty C. de Boer, Cornelis A.M. van Bergen, Harry Dolstra, J.H. Frederik Falkenburg, Marieke Griffioen   +11 more
doaj   +2 more sources

Concurrent detection of circulating minor histocompatibility antigen-specific CD8+ T cells in SCT recipients by combinatorial encoding MHC multimers. [PDF]

PLoS ONE, 2011
Allogeneic stem cell transplantation (SCT) is a potentially curative treatment for patients with hematologic malignancies. Its therapeutic effect is largely dependent on recognition of minor histocompatibility antigens (MiHA) by donor-derived CD8⁺ T ...
Kelly Broen, Annelies Greupink-Draaisma, Rob Woestenenk, Nicolaas Schaap, Anthony G Brickner, Harry Dolstra   +5 more
doaj   +2 more sources

A polymorphism in the splice donor site of ZNF419 results in the novel renal cell carcinoma-associated minor histocompatibility antigen ZAPHIR. [PDF]

PLoS ONE, 2011
Nonmyeloablative allogeneic stem cell transplantation (SCT) can induce remission in patients with renal cell carcinoma (RCC), but this graft-versus-tumor (GVT) effect is often accompanied by graft-versus-host disease (GVHD).
Kelly Broen, Henriette Levenga, Johanna Vos, Kees van Bergen, Hanny Fredrix, Annelies Greupink-Draaisma, Michel Kester, J H Frederik Falkenburg, Pieter de Mulder, Theo de Witte, Marieke Griffioen, Harry Dolstra   +11 more
doaj   +2 more sources

Trophoblast expression of the minor histocompatibility antigen HA-1 is regulated by oxygen and is increased in placentas from preeclamptic women [PDF]

Placenta, 2015
Eric Wickström, Margaret G Petroff
exaly   +2 more sources

T-Cell Immunotherapies Targeting Histocompatibility and Tumor Antigens in Hematological Malignancies

Frontiers in Immunology, 2020
Over the last decades, T-cell immunotherapy has revealed itself as a powerful, and often curative, strategy to treat blood cancers. In hematopoietic cell transplantation, most of the so-called graft-vs.-leukemia (GVL) effect hinges on the recognition of ...
Valérie Janelle, Caroline Rulleau, Simon Del Testa, Cédric Carli, Jean-Sébastien Delisle, Jean-Sébastien Delisle, Jean-Sébastien Delisle   +6 more
doaj   +1 more source

The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction

Frontiers in Immunology, 2020
For hundreds of thousands of years, the human genome has extensively evolved, resulting in genetic variations in almost every gene. Immunological reflections of these genetic variations become clearly visible after an allogeneic stem cell transplantation
Tuna Mutis, Anastasia Xagara, Anastasia Xagara, Robbert M. Spaapen, Robbert M. Spaapen   +4 more
doaj   +1 more source

Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity

Haematologica, 2012
Background Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation.
Marieke Griffioen, M. Willy Honders, Edith D. van der Meijden, Simone A.P. van Luxemburg-Heijs, Ellie G.A. Lurvink, Michel G.D. Kester, Cornelis A.M. van Bergen, J.H. Frederik Falkenburg   +7 more
doaj   +1 more source

Identification of minor histocompatibility antigens based on the 1000 Genomes Project

Haematologica, 2014
Minor histocompatibility antigens are highly immunogeneic polymorphic peptides playing crucial roles in the clinical outcome of HLA-identical allogeneic stem cell transplantation.
Rimke Oostvogels, Henk M. Lokhorst, Monique C. Minnema, Maureen van Elk, Kelly van den Oudenalder, Eric Spierings, Tuna Mutis, Robbert M. Spaapen   +7 more
doaj   +1 more source

Successful generation of primary virus-specific and anti-tumor T-cell responses from the naïve donor T-cell repertoire is determined by the balance between antigen-specific precursor T cells and regulatory T cells

Haematologica, 2011
Background One of the major challenges in allogeneic stem cell transplantation is to find a balance between the harmful induction of graft-versus-host disease and the beneficial graft-versus-leukemia and pathogen-specific immune responses.
Inge Jedema, Marian van de Meent, Jeanette Pots, Michel G.D. Kester, Martha T. van der Beek, J.H. Frederik Falkenburg   +5 more
doaj   +1 more source