Results 181 to 190 of about 30,121 (265)
The TCXpress lane to T-cell receptor-engineered T cells. [PDF]
Biernacki MA.
europepmc +1 more source
This study compared clinical outcomes and immune reconstitution in haplo‐HSCT patients receiving PTCY (n = 45), ATG (n = 45), or PTCY+ATG (n = 45). The ATG group had superior OS (p = 0.029) and LFS (p = 0.034), with higher CD3+ and CD8+ T‐cell counts at 3 months.
Xiao‐Di Ma +11 more
wiley +1 more source
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu +3 more
wiley +1 more source
Endometrial cancer (EC), a major gynecologic malignancy and a representative “cold tumor”, exhibits a tumor immune microenvironment (TIME) influenced by a broad range of cellular and molecular elements, immunosuppressive signals, and pathways of immune evasion.
Jingxuan Ye +4 more
wiley +1 more source
Current Status of Kidney Xenotransplantation in Basic Research
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley +1 more source
Optimal donor selection for transplant to reduce GVHD risk and augment graft-versus-malignancy efficacy. [PDF]
Shaffer BC, Shaw BE.
europepmc +1 more source
Effects of selective harvest on antler size of white‐tailed deer in Texas, USA
We conducted 20 years of experiments on the selective harvest of white‐tailed deer by antler size, judged inferior, in 2 areas of South Texas, USA. Selective harvest increased the phenotypic antler size of older males in one study area but not the other. There was little evidence of evolution resulting from selective harvesting. Abstract There has been
Don A. Draeger +8 more
wiley +1 more source
Aging impairs vaccine efficacy through gut microbiota dysbiosis and mTOR hyperactivation, which together drive inflammaging and weaken immune memory. This review highlights the bidirectional microbiota–mTOR axis and proposes that combining mTOR inhibitors with microbiota modulation offers a promising strategy to enhance vaccine responses in older ...
Jiaxuan Li +5 more
wiley +1 more source
Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm +9 more
wiley +1 more source

