Maternal CD4⁺ and CD8⁺ T cell tolerance towards a fetal minor histocompatibility antigen in T cell receptor transgenic mice. [PDF]
Perchellet AL, Jasti S, Petroff MG.
europepmc +1 more source
This graphical abstract summarizes the in silico design of the multi‐epitope vaccine candidate Rpf‐Toxo (Seq4) against Toxoplasma gondii. The workflow includes antigen selection, epitope mapping, vaccine construction, structural and immunological evaluation, toll‐like receptor‐4 docking, immune simulation, safety assessment, codon optimisation and ...
Mohamad Hosein Safari +7 more
wiley +1 more source
Structure and expression of the human globin genes and murine histocompatibility antigen genes [PDF]
Grosveld, F. +28 more
core +1 more source
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo +7 more
wiley +1 more source
Protective and Pathogenic Antibodies to Citrullinated Antigens
ABSTRACT Autoimmune diseases start years before clinical onset. In rheumatoid arthritis (RA), autoantibodies to citrullinated proteins (ACPA) and to modified IgG (rheumatoid factors, RF) can be detected many years before the inflammatory attack on cartilaginous joints. It has been assumed that these antibodies are pathogenic.
Outi Sareila +5 more
wiley +1 more source
T-cell receptor repertoires against HLA class I-restricted minor histocompatibility antigens are highly diverse with a small subset of public clonotypes. [PDF]
Fuchs KJ +9 more
europepmc +1 more source
Characterization of CTL Clones Specific for Single Antigen, H60 Minor Histocompatibility Antigen. [PDF]
Jeon JY, Jung KM, Chang J, Choi EY.
europepmc +1 more source
Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs +6 more
wiley +1 more source
An Approach to Antibody‐Mediated Rejection in Pediatric Liver Transplantation
ABSTRACT Antibody‐mediated rejection (AMR) is an important but infrequent cause of pediatric liver allograft injury. There is a lack of standardized guidance, and treatment approaches vary across institutions. A writing group from the Society of Pediatric Liver Transplantation conducted a comprehensive review of the published literature and collected ...
Catalina Jaramillo +8 more
wiley +1 more source
Non‐HLA Antibody‐Associated Hyperacute Allograft Rejection Following Lung Transplantation
ABSTRACT Background Pediatric‐onset pulmonary hypertension (PH) is a rare, progressive pulmonary vascular disease associated with high mortality. In cases unresponsive to pharmacological therapy with a severe cardiorespiratory phenotype, lung transplantation (LT) remains the final treatment option. Although LT for pediatric PH is considered a procedure
Justyna A. Karolak +11 more
wiley +1 more source

