Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle
ABSTRACT Integrative genomics combines data from different omics sources to link genotypes and phenotypes with the aim of unravelling biological networks and pathways that undergird complex traits, particularly with respect to disease. In this respect, integrative genomics, leveraging population and functional genomic data, can be employed to ...
Gillian P. McHugo +10 more
wiley +1 more source
ABSTRACT Captive breeding can be a key component of species conservation strategies, but also exposes these rare species to novel environments including the pathogen landscape. The critically endangered white‐winged wood duck (WWWD) Asarcornis scutulata has experienced substantial population declines, local extirpations and fragmentation of its former ...
Peri E. Bolton +5 more
wiley +1 more source
Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation. [PDF]
Porcheray F +9 more
europepmc +1 more source
Don't Cut the Cord: Why Umbilical Cord Blood Still Deserves a Place in Transplantation
ABSTRACT The use of umbilical cord blood (UCB) as a stem cell source in haematopoietic stem cell transplant (HSCT) has greatly declined in recent years. It has largely been replaced by mismatched unrelated and family donors, facilitated by advances in transplant technologies, including post‐transplant cyclophosphamide to prevent graft‐versus‐host ...
Jenna Nunn, Kay Poulton, Robert Wynn
wiley +1 more source
Transfusion of minor histocompatibility antigen-mismatched platelets induces rejection of bone marrow transplants in mice. [PDF]
Patel SR +3 more
europepmc +1 more source
Induction of Clinical Operational Tolerance Through Immunosuppression Minimization: Less Is More?
ABSTRACT The goal of achieving clinical operational tolerance in liver transplantation has sparked significant interest, driven by the desire to mitigate the long‐term adverse effects of immunosuppression. Advances in understanding the immunological mechanisms underpinning operational tolerance in liver transplantation have highlighted the central role
Emilia Knioła +4 more
wiley +1 more source
Major Histocompatibility Complex Class I Matching is Necessary but not Sufficient for Tolerance Induction to Vascularized Composite Allografts After Donor Hematopoietic Cell Transplantation. [PDF]
Manell E +19 more
europepmc +1 more source
Abstract Background and Objectives Adequate representation of donors from diverse ancestral populations in blood, stem cell and organ transplantation is critical to ensuring equitable access to these lifesaving therapies. Because of population‐level differences in genetic markers, patients from racialized groups may have unique transfusion and ...
Bonnie Lu +9 more
wiley +1 more source
Identification of a persistent Ascaris-derived Kalirin epitope associated with chronic T cell activation in the lung. [PDF]
Wu Y, Versteeg L, Wu MC, Weatherhead JE.
europepmc +1 more source
Towards effective and safe immunotherapy after allogeneic stem cell transplantation: identification of hematopoietic-specific minor histocompatibility antigen UTA2-1. [PDF]
Oostvogels R +12 more
europepmc +1 more source

