In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle +6 more
wiley +1 more source
Major and minor histocompatibility antigens to NIMA: Prediction of a tolerogenic NIMA effect. [PDF]
Hirayama M, Azuma E.
europepmc +1 more source
Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe +2 more
wiley +1 more source
The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ
ABSTRACT The thymus is emerging as a model for studying organ regeneration and stem cell biology. While research has long focused on how antigen‐presenting cells shape the T cell repertoire, recent discoveries unveil a far richer cellular landscape that challenges long‐held views of thymus structure and function. This review traces the history of early
Roberta Ragazzini, Paola Bonfanti
wiley +1 more source
Minor histocompatibility antigens are expressed in syncytiotrophoblast and trophoblast debris: implications for maternal alloreactivity to the fetus. [PDF]
Holland OJ +7 more
europepmc +1 more source
Allogeneic orthotopic liver transplantation in mice: a preliminary study of rejection across well-defined MHC barriers. [PDF]
Demetris, AJ +3 more
core
oxPAPC‐Mediated lncRNA CYP1B1‐AS1 From Dendritic Cells Accelerates Atherosclerosis
ABSTRACT Oxidised 1‐palmitoyl‐2‐arachidonoyl‐sn‐glycero‐3‐phosphorylcholine (oxPAPC), dendritic cells (DCs), and long non‐coding RNAs (lncRNAs) play crucial roles in atherosclerosis (AS). This study aimed to determine whether oxPAPC‐induced DC‐derived lncRNAs contribute to AS and to elucidate the underlying regulatory mechanisms.
Yuheng Cheng +9 more
wiley +1 more source
Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia. [PDF]
Bleakley M, Riddell SR.
europepmc +1 more source
Landscapes of HLA Mismatching in Contemporary Unrelated Haematopoietic Cell Transplantation
ABSTRACT Haematopoietic cell transplantation (HCT) with HLA‐mismatched unrelated donors (MMUD) offers access to curative therapy for patients lacking well‐matched donors. Accumulating evidence suggests that functional matching among allele‐mismatched pairs can significantly influence patient outcomes.
Esteban Arrieta‐Bolaños +21 more
wiley +1 more source
High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations. [PDF]
Hombrink P +7 more
europepmc +1 more source

