Results 91 to 100 of about 13,589 (276)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Orobancheingens (Orobanchaceae) - a poorly known species of the Greater Caucasus: taxonomic problems, distribution, hosts and habitats. [PDF]
PhytoKeys, 2022 Piwowarczyk R +3 more
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The role of parental health beliefs in seeking an eye examination for their child. [PDF]
BMC Ophthalmol, 2023 Masarwa D +3 more
europepmc +1 more source
Nebrija y Maquiavelo ante un epigrama de Ausonio: paratexto y texto
Cuadernos de Filología Italiana, 2007 This article analyses the presence of an epigram by the poet Ausonio (IV AD) in Nebrija and in Machiavelli. The text by Ausonio, which in turn derived from a Greek text by Posidipo (III BC), must have been familiar to the European Humanism, since it ...
Cristina Barbolani
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
[Bilateral vocal cord paralysis with acute airway obstruction and urgent tracheotomy in a patient with an acute vertebrobasilar stroke]. [PDF]
Rev Neurol, 2023 Díaz-Pérez C +4 more
europepmc +1 more source
Quelques remarques sur la responsabilité de la « custodia » en droit privé romain classique [PDF]
, 2015 Dans cette étude, quelques questions de la responsabilité de la « custodia » sont examinées en droit romain. Tout d’abord, les interprétations romanistiques concernant la responsabilité de la « custodia » sont résumées ; l’auteur soutient principalement ...
Siklósi, Iván
core +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source